Evidence map›Paper›PMID 40563463›Full record

ReviewBiomolecules2025

Antechodynamics and Antechokinetics: Dynamics and Kinetics of Antibiotic Resistance Biomolecules.

F Baquero, R Cantón, A E Pérez-Cobas, T M Coque, B Levin, J Rodríguez-Beltrán

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

F BaqueroDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0002-7930-3033
R CantónDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0003-1675-3173
A E Pérez-CobasDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0002-3995-5571
T M CoqueDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research (IRYCIS), 28034 Madrid, Spain.ORCID 0000-0002-8228-3491
B LevinDepartment of Biology, Emory University, Atlanta, GA 30322, USA.
J Rodríguez-BeltránDepartment of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Institute for Health Research (IRYCIS), 28034 Madrid, Spain.

Funding

Single Cell Analysis Core (Core C)U19AI158080 · NIAID · EMORY UNIVERSITY · PI LEVIN, BRUCE RICHARD, WEISS, DAVID S · 2021 to 2025
$10.9M
Theoretical and Experimental Studies of the Population and Evolutionary Dynamics of Bacteria and Bacteriophage.R35GM136407 · NIGMS · EMORY UNIVERSITY · PI LEVIN, BRUCE RICHARD · 2020 to 2024
$2.0M
Instituto de Salud Carlos III - CIBERESP CB06/02/0053NIAID NIH HHS U19 AI158080NIGMS NIH HHS R35 GM136407
6 · The paper itself

Abstract

The pharmacology of antimicrobial agents comprises pharmacodynamics and pharmacokinetics. Pharmacodynamics refers to studying drugs' mode of action on their molecular targets at various concentrations and the resulting effect(s). Pharmacokinetics refers to studying the way(s) in which drugs enter the body and are distributed to their targets in various compartments (such as tissues) and how local drug concentrations are modified in time, such as by metabolism or excretion. Pharmacodynamics and pharmacokinetics constitute pivotal knowledge for establishing the breakpoints used to identify the appropriate antimicrobial agents for infection therapy. Antibiotic resistance is the biological force opposing antimicrobials' pharmacological effects. However, we do not have a term similar to pharmacology for microbial antibiotic resistance reactions. Here, we propose the new scientific field of antechology (from the classic Greek

Indexed as

Anti-Bacterial AgentsBacteriaDrug Resistance, BacterialDrug Resistance, MicrobialHumansKineticsAnti-Bacterial Agentsantechodynamicsantechokineticsantechologyantibiotic resistanceantibioticspharmacodynamicspharmacokinetics

Identifiers

PMID40563463
PMCPMC12190993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.