Evidence map›Paper›PMID 40563462›Full record

ArticleBiomolecules2025

Biochemical and Functional Characterization of

Xiabin Chen, Yishuang Li, Jianzhuang Yao, Xiaoxuan Li, Hualing Li, Zelin Wu, Qi Hu, Nuo Xu, Tingjun Hou, Jiye Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Leucine Aminopeptidase fromBiomolecules · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiabin ChenSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Yishuang LiSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Jianzhuang YaoSchool of Biological Science and Technology, University of Jinan, Jinan 250022, China.ORCID 0000-0002-5017-3677
Xiaoxuan LiSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Hualing LiSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Zelin WuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Qi HuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Nuo XuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Tingjun HouCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Jiye WangKey Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou 310053, China.
Shurong HouSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.

Funding

Interdisciplinary Research Project of Hangzhou Normal University 2025JCXK02National Natural Science Foundation of China 82073749, 22273032STI2030-Major Projects 2022ZD0214600
6 · The paper itself

Abstract

6-monoacetylmorphine (6-MAM), a primary active metabolite of heroin that reaches the human brain, plays a crucial role in producing heroin-associated physiological and lethal effects. Therefore, 6-MAM has emerged as a key target for alleviating the adverse consequences of heroin abuse. In this study, the proposed 6-MAM hydrolase

Indexed as

CD13 AntigensEscherichia coliEscherichia coli ProteinsMorphine DerivativesHumansHydrogen-Ion ConcentrationKineticsRecombinant ProteinsSubstrate Specificity6-O-monoacetylmorphineCD13 AntigensEscherichia coli ProteinsMorphine DerivativesRecombinant Proteinsbiochemical propertycatalytic functionEscherichia coli aminopeptidase Nheroin and 6-MAM

Identifiers

PMID40563462
PMCPMC12190285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.