Evidence map›Paper›PMID 40563453›Full record

ArticleBiomolecules2025

Brusatol Inhibits Esophageal Squamous Cell Carcinoma Tumorigenesis Through Bad-Mediated Mitochondrial Apoptosis Induction and Anti-Metastasis by Targeting Akt1.

Yao Ji, Xinxin Zhu, Yi Shi, Rui Fang, Yimeng Sun, Yurong Ruan, Liying Zhou, Yuanyuan Ge, Qichao Luo, Junyan Zhang and 1 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yao JiDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Xinxin ZhuDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.ORCID 0009-0005-3466-9268
Yi ShiDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Rui FangDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Yimeng SunDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Yurong RuanDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Liying ZhouDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Yuanyuan GeDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Qichao LuoDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Junyan ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Junting MaDepartment of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.

Funding

Anhui Medical University clinical medicine ('5+3' integration) early contact research projects 2022-ZQKY-197Anhui Medical University clinical medicine ('5+3' integration) early contact research projects 2023-ZQKY-088National Natural Science Foundation of China 82203284
6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is a prevalent malignancy characterized by poor prognosis and a deficiency of effective therapies. Brusatol (Bru), a bioactive component derived from

Indexed as

Apoptosisbcl-Associated Death ProteinEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaMitochondriaProto-Oncogene Proteins c-aktQuassinsAnimalsCarcinogenesisCell Line, TumorCell ProliferationHumansMiceMice, Inbred BALB CNeoplasm MetastasisAKT1 protein, humanBAD protein, humanbcl-Associated Death ProteinbrusatolProto-Oncogene Proteins c-aktQuassinsAkt1Brusatolesophageal squamous cell carcinomametastasismitochondria apoptosis

Identifiers

PMID40563453
PMCPMC12191141

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.