Evidence map›Paper›PMID 40563439›Full record

ArticleBiomolecules2025

Increased [

Cecilia Marini, Mattia Riondato, Edoardo Dighero, Alessia Democrito, Serena Losacco, Laura Emionite, Lucilla Nobbio, Irene Di Patrizi, Mattia Camera, Chiara Ghersi and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Cecilia MariniInstitute of BioImaging and Complex Biological Systems, National Research Council (CNR), 20054 Milan, Italy.
Mattia RiondatoNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.ORCID 0000-0001-9046-7170
Edoardo DigheroNuclear Medicine, Department of Health Science, University of Genoa, 16132 Genoa, Italy.
Alessia DemocritoNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.
Serena LosaccoNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.
Laura EmioniteAnimal Facility, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.
Lucilla NobbioClinica Neurologica Unit, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.ORCID 0000-0003-2150-3953
Irene Di PatriziRadiology Unit, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.
Mattia CameraDINOGMI, University of Genova, 16132 Genoa, Italy.ORCID 0000-0003-4257-0629
Chiara GhersiNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.
Maddalena GhelardoniNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.ORCID 0009-0007-8211-1343
Francesco LanfranchiNuclear Medicine, Department of Health Science, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-6043-9627
Francesca VitaleNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.
Sonia CartaNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.ORCID 0000-0002-1278-9761
Sabrina ChiesaNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.
Carola TorazzaPharmacology, Department of Pharmacy, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-2236-5142
Marco MilanesePharmacology, Department of Pharmacy, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0003-3384-0666
Matteo BaucknehtNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.ORCID 0000-0002-1937-9116
Mehrnaz HamedaniDINOGMI, University of Genova, 16132 Genoa, Italy.ORCID 0000-0002-9371-4832
Federico ZaottiniRadiology, Department of Health Science, University of Genoa, 16132 Genoa, Italy.
Angelo SchenoneClinica Neurologica Unit, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.ORCID 0000-0002-2604-7830
Carlo MartinoliRadiology, Department of Health Science, University of Genoa, 16132 Genoa, Italy.
Federica GrilloPathology Unit, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.ORCID 0000-0001-6477-3182
Gianmario SambucetiNuclear Medicine, IRCCS Ospedale Policlinico San Martino di Genova, 16132 Genoa, Italy.

Funding

Italian Ministry of Health RF-2018-12366238
6 · The paper itself

Abstract

purposeThe skeletal muscle has been proposed to contribute to the progressive loss of motor neurons typical of amyotrophic lateral sclerosis (ALS). However, this mechanism has not yet been clarified due to the lack of suitable imaging tools. Here, we aimed to verify whether PET imaging of the translocator protein 18 kDa (TSPO) can detect a muscular abnormality in an experimental model of ALS.

methodsIn vivo biodistribution and kinetics of [

results[

conclusionUpregulation of TSPO expression is characteristic of skeletal muscle, but not the brain, in the experimental SOD1

Indexed as

Amyotrophic Lateral SclerosisMuscle, SkeletalPyrazolesPyrimidinesReceptors, GABASuperoxide Dismutase-1AnimalsBrainDisease Models, AnimalFluorine RadioisotopesHumansMaleMiceMice, TransgenicPositron-Emission TomographyTissue DistributionBzrp protein, mouseFluorine-18Fluorine RadioisotopesN,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamidePyrazolesPyrimidinesReceptors, GABASuperoxide Dismutase-1[18F]DPA-714ALSbrainPETskeletal muscleTSPO

Identifiers

PMID40563439
PMCPMC12190601

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.