Evidence map›Paper›PMID 40563437›Full record

ReviewBiomolecules2025

Tuning Autophagy for Improved Liver Transplant Outcomes: Insights from Experimental Models.

Mina Kolahdouzmohammadi, Graziano Oldani

Abstract readReview
In one paragraph

Review in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mina KolahdouzmohammadiDepartment of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Graziano OldaniDepartment of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver transplantation faces significant challenges, primarily due to the severe shortage of organs-aggravated by the increasing prevalence of liver diseases-and graft loss due to the consequences of ischemia/reperfusion injury (I/RI) and rejection. A recent study highlights the critical role of autophagy, a cellular breakdown and recycling mechanism, in addressing these issues. This article examines the role of autophagy in liver transplantation, focusing on organ preservation and recovery after surgery, as well as its potential to regulate immune responses and increase graft survival. Additionally, it will cover the role of autophagy in xenotransplantation, a prospective solution to the organ scarcity crisis. Ultimately, it assesses the importance of precisely timing autophagy modulation-whether induction or inhibition-to enhance transplantation outcomes, while identifying key knowledge gaps and future research directions.

Indexed as

AutophagyLiver TransplantationAnimalsGraft RejectionGraft SurvivalHumansLiverReperfusion InjuryTransplantation, Heterologousautophagygraft rejectionliver transplantationxenotransplantation

Identifiers

PMID40563437
PMCPMC12191164

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.