Evidence map›Paper›PMID 40563432›Full record

ArticleBiomolecules2025

Optimizing C-Type Natriuretic Peptide and Receptor Expression Analysis with Droplet Digital™ PCR: Advancing Biomarker Discovery for Brugada Syndrome?

Manuela Cabiati, Federico Vozzi, Elisa Persiani, Marcello Piacenti, Andrea Rossi, Agnese Sgalippa, Antonella Cecchettini, Gianluca Solarino, Giulio Zucchelli, Lorenzo Mazzocchetti and 4 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Manuela CabiatiLaboratory of Biochemistry and Molecular Biology, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Federico VozziLaboratory of Biochemistry and Molecular Biology, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Elisa PersianiLaboratory of Biochemistry and Molecular Biology, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Marcello PiacentiFondazione Toscana Gabriele Monasterio, 56124 Pisa, Italy.
Andrea RossiFondazione Toscana Gabriele Monasterio, 56124 Pisa, Italy.ORCID 0000-0003-4430-6821
Agnese SgalippaLaboratory of Biochemistry and Molecular Biology, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Antonella CecchettiniLaboratory of Biochemistry and Molecular Biology, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.ORCID 0000-0002-2659-026X
Gianluca SolarinoUniversity Cardiology Division, Versilia Hospital, 55041 Lido di Camaiore, Italy.ORCID 0009-0002-7919-3759
Giulio ZucchelliSecond Division of Cardiology, Azienda Ospedaliero Universitaria Pisana, 56126 Pisa, Italy.ORCID 0000-0001-7274-4541
Lorenzo MazzocchettiSecond Division of Cardiology, Azienda Ospedaliero Universitaria Pisana, 56126 Pisa, Italy.
Pasquale NotarstefanoCardiovascular and Neurological Department, San Donato Hospital, 52100 Arezzo, Italy.ORCID 0000-0003-0740-0464
Letizia GuiducciLaboratory of Biochemistry and Molecular Biology, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Maria Aurora MoralesLaboratory of Biochemistry and Molecular Biology, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Silvia Del RyLaboratory of Biochemistry and Molecular Biology, CNR Institute of Clinical Physiology, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.ORCID 0000-0001-7163-245X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brugada syndrome (BrS) is a cardiac disease associated with characteristic ECG abnormalities and a heightened risk of sudden cardiac death, especially in young individuals with structurally normal hearts. The primary aim of this study was to highlight, for the first time, the potential of using droplet digital PCR (ddPCR), a highly sensitive method, to detect

Indexed as

Brugada SyndromeNatriuretic Peptide, C-TypePolymerase Chain ReactionReceptors, Atrial Natriuretic FactorAdultAtrial Natriuretic Factor Receptor BBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedAtrial Natriuretic Factor Receptor Batrial natriuretic factor receptor CBiomarkersNatriuretic Peptide, C-TypeReceptors, Atrial Natriuretic FactorBrugada syndromeC-type natriuretic peptidedroplet digital™ PCRmRNANPR-BNPR-C

Identifiers

PMID40563432
PMCPMC12190965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.