Evidence map›Paper›PMID 40563368›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Redox Imbalance Is Associated with Neuronal Apoptosis in the Cortex of Neonates Gestated Under Chronic Hypoxia.

Esteban G Figueroa, Rodrigo L Castillo, Adolfo A Paz, Matías Monsalves-Alvarez, Francisca Salas-Pérez, Ximena Calle, Tamara A Jiménez, Emilio A Herrera, Alejandro Gonzaléz-Candia

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Barriers to HPV Vaccination in Brazil: A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Esteban G FigueroaLaboratory of Fetal Neuroprogramming, Institute of Health Sciences, Universidad de O'Higgins, Rancagua 3655000, Chile.ORCID 0000-0003-1316-738X
Rodrigo L CastilloDepartment of Internal Medicine East, Faculty of Medicine, Universidad de Chile, Santiago 7500922, Chile.
Adolfo A PazLaboratory of Vascular Function & Reactivity, Pathophysiology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago 8330015, Chile.ORCID 0000-0003-4611-2748
Matías Monsalves-AlvarezExercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andrés Bello, Santiago 7610196, Chile.ORCID 0000-0003-3163-3911
Francisca Salas-PérezInstitute of Health Sciences, Universidad de O'Higgins, Rancagua 3655000, Chile.
Ximena CalleInstitute of Health Sciences, Universidad de O'Higgins, Rancagua 3655000, Chile.
Tamara A JiménezLaboratory of Vascular Function & Reactivity, Pathophysiology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago 8330015, Chile.
Emilio A HerreraLaboratory of Vascular Function & Reactivity, Pathophysiology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago 8330015, Chile.ORCID 0000-0002-6342-085X
Alejandro Gonzaléz-CandiaLaboratory of Fetal Neuroprogramming, Institute of Health Sciences, Universidad de O'Higgins, Rancagua 3655000, Chile.

Funding

Fondecyt Regular 1241626
6 · The paper itself

Abstract

Gestational chronic hypoxia impacts prenatal development, leading to fetal growth restriction (FGR), defined as the fetus's failure to reach its genetic growth potential. Postnatal hypoxia in the cerebral tissue can induce a redox imbalance and mitochondrial dysfunction, consequently increasing neuronal death. However, these data cannot necessarily be extrapolated to prenatal hypoxia. In this regard, this study aims to describe the effect of gestational hypoxia on redox balance and apoptosis cell death mechanisms in the prefrontal cortex of guinea pigs. Ten Guinea pig (

Indexed as

intrauterine chronic hypoxiamitochondrial dysfunctionneuron deathoxidative stress

Identifiers

PMID40563368
PMCPMC12189337

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.