Evidence map›Paper›PMID 40563343›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Subchronic Intranasal Administration of NeuroEPO Reduces Long-Term Consequences of Severe Traumatic Brain Injury in Male Rats.

Félix Iván López-Preza, Maria de Los Angeles Nuñez-Lumbreras, Iliana Sosa-Testé, Alonso Fernández-Guasti, Luis Concha, Teresita Rodríguez-Obaya, Luisa Rocha

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Félix Iván López-PrezaPharmacobiology Department, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV), Mexico City C.P. 14330, Mexico.ORCID 0000-0001-6789-8730
Maria de Los Angeles Nuñez-LumbrerasPharmacobiology Department, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV), Mexico City C.P. 14330, Mexico.ORCID 0000-0001-6013-1270
Iliana Sosa-TestéCenter for the Production of Laboratory Animals (CENPALAB), Havana C.P. 10300, Cuba.ORCID 0000-0001-6588-5397
Alonso Fernández-GuastiPharmacobiology Department, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV), Mexico City C.P. 14330, Mexico.ORCID 0000-0003-1283-8911
Luis ConchaInstitute of Neurobiology, National Autonomous University of Mexico, Campus Juriquilla, Juriquilla C.P. 76230, Queretaro, Mexico.ORCID 0000-0002-7842-3869
Teresita Rodríguez-ObayaCenter for Molecular Immunology (CIM), Havana C.P. 11600, Cuba.ORCID 0000-0002-2918-4267
Luisa RochaPharmacobiology Department, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV), Mexico City C.P. 14330, Mexico.ORCID 0000-0003-4495-9427

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías Grant 322515 and scholarship 839363
6 · The paper itself

Abstract

Current treatments fail to prevent long-term consequences induced by a severe traumatic brain injury (TBI). This study aimed to evaluate the efficacy of repetitive intranasal administration of NeuroEPO (a derivative of erythropoietin) on long-term alterations after a severe TBI induced by the application of a lateral fluid percussion in male rats. A otal of 30-31 days after the trauma, TBI+vehicle group showed sensorimotor dysfunction (Neuroscore,

Indexed as

depression-like behaviormagnetic resonance imagingNeuroEPOoxidative stresssensorimotor functiontraumatic brain injury

Identifiers

PMID40563343
PMCPMC12189735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.