Evidence map›Paper›PMID 40563241›Full record

ArticleThe Journal of physiology2025

Pancreatic acinar cell signalling and function exhibit an absolute requirement for activation of Gα

Takahiro Takano, Luca Franchini, Larry E Wagner, Michelle Cooley, Guy E Groblewski, Cesare Orlandi, David I Yule

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and GαProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takahiro TakanoDepartment of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.
Luca FranchiniDepartment of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.
Larry E WagnerDepartment of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.
Michelle CooleyDepartment of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0003-3807-3240
Guy E GroblewskiDepartment of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin, USA.
Cesare OrlandiDepartment of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.ORCID 0000-0002-4992-9350
David I YuleDepartment of Pharmacology and Physiology, University of Rochester, Rochester, New York, USA.ORCID 0000-0002-6743-0668

Funding

Role of the ER acetyl CoA transporter in alcoholic pancreatitisR01AA028852 · NIAAA · UNIVERSITY OF WISCONSIN-MADISON · PI GROBLEWSKI, GUY E, LUGEA, AURELIA · 2021 to 2025
$2.4M
Discovery of synthetic and endogenous ligands for orphan GPCR GPR156R01DC022104 · NIDCD · UNIVERSITY OF ROCHESTER · PI Cesare Orlandi · 2024 to 2026
$2.0M
NIAAA NIH HHS R01 AA028852NIDCD NIH HHS R01 DC022104
6 · The paper itself

Abstract

Elevated cytoplasmic [Ca

Indexed as

Acinar CellsGTP-Binding Protein alpha Subunits, Gq-G11PancreasAcetylcholineAnimalsCalciumCalcium SignalingCholecystokininMaleMiceMice, Inbred C57BLPeptides, CyclicProtein Kinase CReceptor, Muscarinic M3Signal TransductionAcetylcholineCalciumCholecystokininGTP-Binding Protein alpha Subunits, Gq-G11Peptides, CyclicProtein Kinase CReceptor, Muscarinic M3YM-254890Ca2+ signallingdiacylglycerolexocytosisGαq/11inositol 1,4,5‐trisphosphatenicotinic acid dinucleotide adenine phosphatepancreatic acinar cellsYM‐254890

Identifiers

PMID40563241
PMCPMC13320608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.