Evidence map›Paper›PMID 40563233›Full record

ArticleJournal of the American Chemical Society2025

μMap-FFPE: A High-Resolution Protein Proximity Labeling Platform for Formalin-Fixed Paraffin-Embedded Tissue Samples.

Noah B Bissonnette, Marie E Zamanis, Steve D Knutson, Zane Boyer, Angelo Harris, Daniel Martin, Jacob B Geri, Suzana Couto, Tahamtan Ahmadi, Anantharaman Muthuswamy and 2 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. A unified photosensitizer platform forbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Noah B BissonnetteMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0001-6892-5040
Marie E ZamanisGenmab US, Inc., Building 2, 777 Scudders Mill Rd, Princeton, New Jersey 08540, United States.
Steve D KnutsonMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.
Zane BoyerMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.ORCID 0009-0002-3739-9134
Angelo HarrisGenmab US, Inc., Building 2, 777 Scudders Mill Rd, Princeton, New Jersey 08540, United States.
Daniel MartinGenmab US, Inc., Building 2, 777 Scudders Mill Rd, Princeton, New Jersey 08540, United States.
Jacob B GeriMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0002-9215-5610
Suzana CoutoGenmab US, Inc., Building 2, 777 Scudders Mill Rd, Princeton, New Jersey 08540, United States.
Tahamtan AhmadiGenmab US, Inc., Building 2, 777 Scudders Mill Rd, Princeton, New Jersey 08540, United States.
Anantharaman MuthuswamyGenmab US, Inc., Building 2, 777 Scudders Mill Rd, Princeton, New Jersey 08540, United States.
Mark FereshtehGenmab US, Inc., Building 2, 777 Scudders Mill Rd, Princeton, New Jersey 08540, United States.
David W C MacMillanMerck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0001-6447-0587

Funding

Photoredox Catalysis Applications in Organometallics and Chemical BiologyR35GM134897 · NIGMS · PRINCETON UNIVERSITY · PI David W MacMillan · 2020 to 2026
$6.3M
Mechanistic Interrogation of Long Non-coding RNAs using Photocatalytic Proximity Labeling and CRISPR Phenotypic ProfilingK99GM154140 · NIGMS · PRINCETON UNIVERSITY · PI KNUTSON, STEVEN DOUGLAS · 2024 to 2025
$250k
High-Resolution Mapping of Subcellular RNA Dynamics Using Photocatalytic Proximity LabelingF32GM142206 · NIGMS · PRINCETON UNIVERSITY · PI KNUTSON, STEVEN DOUGLAS · 2021 to 2023
$202k
NIGMS NIH HHS F32 GM142206NIGMS NIH HHS K99 GM154140NIGMS NIH HHS R35 GM134897
6 · The paper itself

Abstract

Many disease states can be understood by elucidating small-scale biomolecular protein interaction networks, or microenvironments. Photoproximity labeling methods, like μMap, have recently emerged as high-resolution techniques for mapping spatial relationships within subcellular architectures. However,

Indexed as

Antigens, CD20FormaldehydeParaffin EmbeddingProteinsTissue FixationHumansStaining and LabelingAntigens, CD20FormaldehydeProteins

Identifiers

PMID40563233
PMCPMC12337457

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.