ArticlePediatric blood & cancer2025
Clinical Features and Outcomes of Pneumococcal Bacteremia in Children With Sickle Cell Disease in the Pneumococcal Conjugate Vaccine Era.
Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionChildren with sickle cell disease (SCD) are at higher risk for invasive infection with Streptococcus pneumoniae compared with the general pediatric population. Penicillin prophylaxis, pneumococcal conjugate (PCV), and polysaccharide vaccines (PPSV) have reduced but not eliminated the risk of pneumococcal bacteremia.
methodsA single institution cohort of children with SCD aged <19 years was reviewed over the 14-year period since PCV13 licensure (January 2010-December 2023) to identify and characterize the clinical features and outcomes of S. pneumoniae bacteremia, including serotypes and antibiotic susceptibility.
resultsThe cohort included 4356 children with SCD (24,076 person-years). Thirty-eight patients with pneumococcal bacteremia were identified (32 HbSS, five HbSC, one HbSβ
conclusionPneumococcal bacteremia continues to be a concern in children with SCD, with a risk of rapid progression to severe disease. Pneumococcal prevention strategies, immunizations, and urgent empiric treatment for fever remain important for children and adolescents of all ages with SCD.
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