Evidence map›Paper›PMID 40563208›Full record

SynthesisJournal of clinical nursing2025

Determinants and Motivations of Vaccination Hesitancy and Uptake in Nurses: A Systematic Review and Meta-Analysis.

Giulia Locatelli, Michela Luciani, Diletta Fabrizi, Beatrice Albanesi, Alessio Conti, Marco Clari, Erika Renzi, Azzurra Massimi, Davide Ausili

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of clinical nursing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giulia LocatelliSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0003-1841-8379
Michela LucianiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-7598-5658
Diletta FabriziSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0002-5152-8804
Beatrice AlbanesiDepartment of Sciences of Public Health and Pediatrics, University of Torino, Torino, Italy.ORCID 0000-0002-7919-2927
Alessio ContiDepartment of Sciences of Public Health and Pediatrics, University of Torino, Torino, Italy.ORCID 0000-0003-4301-8924
Marco ClariDepartment of Sciences of Public Health and Pediatrics, University of Torino, Torino, Italy.ORCID 0000-0001-5927-2973
Erika RenziDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-9760-0245
Azzurra MassimiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-6612-2949
Davide AusiliSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID 0000-0001-5212-6463

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimVaccinations are essential to ensure protection for healthcare professionals, patients and communities. However, vaccination hesitancy has been reported among healthcare professionals. Nurses are the main, first and direct point of contact for patients and citizens in most healthcare services, but only a minority of studies investigated vaccination hesitancy and uptake specifically in this population. Thus, this study aimed to explore the determinants and motivations of vaccination hesitancy and uptake among nurses.

designSystematic review with a narrative synthesis approach.

methodsWe included primary research exploring determinants or motivations of vaccination hesitancy or uptake among nurses. No time or geographical limit was applied. Generalised random-effects linear models with a logit link were used to calculate the pooled estimated proportions for vaccine uptake among nurses. DATA SOURCES: We explored nine databases (2023).

resultsThe initial search identified 3452 records; 42 records were eventually included in this review. Older age, longer professional experience, lack of confidence in vaccine safety and effectiveness and cost associated with the vaccine were among the most common determinants of vaccine hesitancy. Safety concerns, complacency (e.g., beliefs of not needing the vaccine), and accessibility (e.g., logistics) were among the most common motivations for being vaccine hesitant. Having strong confidence in the vaccine, a high sense of collective responsibility, previous vaccination uptake/positive intentions towards future vaccination, weaker vaccine complacency, and older age were among the most common determinants of vaccine uptake. Willingness to protect themselves and/or others, contribute to the herd immunity, and comply with recommendations were among the most common motivations for vaccine uptake. The pooled prevalence of influenza vaccine uptake among nurses was 44% (95% CI: 35-73).

conclusionThe findings of this systematic review with meta-analysis could guide the identification of strategies to reduce barriers and further improve facilitators to eventually increase vaccine uptake in nurses. IMPLICATIONS FOR THE PROFESSION AND/OR PATIENT CARE: This study contributes to further understanding nurses' beliefs, barriers, and facilitators towards vaccination. By doing so, these results could guide the identification of strategies to reduce barriers and further improve facilitators to eventually increase vaccine uptake in nurses. REPORTING

methodWe have adhered to relevant EQUATOR guidelines, in particular to the PRISMA checklist. PATIENT OR PUBLIC CONTRIBUTION: No patient or public contribution.

trial registrationPROSPERO number: CRD42020212252.

Indexed as

MotivationPatient Acceptance of Health CareVaccinationVaccination HesitancyAdultFemaleHumansMaleMiddle Agedmotivationnursessystematic reviewvaccination hesitancyvaccination uptakevaccines

Identifiers

PMID40563208
PMCPMC12409242

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.