Evidence map›Paper›PMID 40563205›Full record

ArticleProtein science : a publication of the Protein Society2025

Prokaryotic mechanosensitive channels mediate copper influx.

Yara Ghnamah, Caitlin D Palmer, Nurit Livnat-Levanon, Moti Grupper, Amy C Rosenzweig, Oded Lewinson

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Copper homeostasis networks in pseudomonas aeruginosa and the organocopper metabolite fluopsin C.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Review
  2. CueO Possesses Copper Detoxification Activity Linking Bacterial Virulence and Drug Resistance in Brucella.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Review
  5. Prokaryotic mechanosensitive channels mediate copper influx.Protein science : a publication of the Protein Society · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yara GhnamahDepartment of Molecular Microbiology and the Rappaport Institute for Medical Sciences, Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel.
Caitlin D PalmerDepartment of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois, USA.
Nurit Livnat-LevanonDepartment of Molecular Microbiology and the Rappaport Institute for Medical Sciences, Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel.
Moti GrupperInfectious Disease Unit, Rambam Health Care Campus, Haifa, Israel.
Amy C RosenzweigDepartment of Molecular Biosciences and Chemistry, Northwestern University, Evanston, Illinois, USA.
Oded LewinsonDepartment of Molecular Microbiology and the Rappaport Institute for Medical Sciences, Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0003-4650-0441

Funding

Molecular Biophysics Training Program at Northwestern UniversityT32GM008382 · NIGMS · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 1990 to 2020
$4.3M
Ames Research Center NNA04CC36GNational Science Foundation (NSF) and United States - Israel Binational Science Foundation (BSF) 1938715NIGMS NIH HHS T32 GM008382NIH HHS T32GM008382Rappaport Institute for Biomedical research 0000
6 · The paper itself

Abstract

Copper is an essential micronutrient in all kingdoms of life, requiring a meticulous balance between acquisition and toxic overload. While copper import in eukaryotes has been investigated extensively, few prokaryotic copper importers have been identified, leading to the notion that cytoplasmic copper uptake is unnecessary in prokaryotes. Here we report that mechanosensitive channels are key players in prokaryotic copper import. Deletion of the gene encoding the Escherichia coli small mechanosensitive channel,

Indexed as

CopperEscherichia coliEscherichia coli ProteinsIon ChannelsMechanotransduction, CellularCopperEscherichia coli ProteinsIon Channelsbacteriacopperion channelsmechanosensitive channelsmembrane permeationmetal homeostasisprokaryotestransport

Identifiers

PMID40563205
PMCPMC12198049

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.