Evidence map›Paper›PMID 40563138›Full record

ArticleRenal failure2025

Urinary and plasma donor-derived cell-free DNA for noninvasive monitoring of BK polyomavirus-associated nephropathy in kidney transplant recipients: a prospective cohort study.

Luying Guo, Sulin Luo, Rongfang Shen, Pengpeng Yan, Meifang Wang, Tianlu Zhang, Junhao Lv, Guangjun Liu, Hongfeng Huang, Zhimin Chen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Luying GuoKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Sulin LuoKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Rongfang ShenKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Pengpeng YanKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Meifang WangKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Tianlu ZhangKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Junhao LvKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Guangjun LiuKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Hongfeng HuangKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Zhimin ChenKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Huiping WangKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Wenhan PengKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Jianyong WuKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Jianghua ChenKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Rending WangKidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBK polyomavirus-associated nephropathy (BKPyVAN) is a major cause of allograft injury and dysfunction in kidney transplant recipients. Current monitoring tools, including viremia and biopsy, have limitations in sensitivity, invasiveness, and timing.

objectiveTo evaluate donor-derived cell-free DNA (dd-cfDNA) in urine and plasma as a dynamic, noninvasive biomarker for monitoring treatment response and predicting rejection risk in patients with biopsy-proven BKPyVAN.

methodsIn this prospective cohort study, 25 kidney transplant recipients with biopsy-proved BKPyVAN were enrolled and stratified into two cohorts: conventional immunosuppression reduction (CISR,

resultsUrinary dd-cfDNA levels significantly declined in the CISR cohort by month 2 (

conclusionCombined urinary and plasma dd-cfDNA measurements are promising for noninvasive, dynamic surveillance of BKPyVAN and rejection risk in kidney transplant recipients. Larger, multicenter studies are warranted to define clinical thresholds and standardize integration into immunosuppression management.

Indexed as

BK VirusCell-Free Nucleic AcidsGraft RejectionKidney DiseasesKidney TransplantationPolyomavirus InfectionsTumor Virus InfectionsAdultAgedBiomarkersBiopsyDNA, ViralFemaleHumansImmunosuppressive AgentsKidneyBiomarkersCell-Free Nucleic AcidsDNA, ViralImmunosuppressive Agentsallograft rejectionBKPyVANdonor-derived cell-free DNAdynamic surveillancekidney transplantation

Identifiers

PMID40563138
PMCPMC12893493

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.