Evidence map›Paper›PMID 40563122›Full record

ArticleCell & bioscience2025

Kv1.1 channel dysfunction in parvalbumin-positive interneurons contributes to anxiety-like behaviors in young adult presenilin 1/2 conditional double knockout mice.

Guang Yang, Yang Zhao, Chenyi Zhao, Jinglan Yan, Yucen Xia, Kun Li, Yongkang Wu, Xingyu Wang, Meng Zhang, Yongjun Chen and 1 more

Abstract read
In one paragraph

Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guang YangDepartment of Physiology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Yang ZhaoDepartment of Physiology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Chenyi ZhaoDepartment of Physiology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Jinglan YanInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Daxue Road, Jinan, 250355, China.
Yucen XiaInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Daxue Road, Jinan, 250355, China.
Kun LiDepartment of Physiology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Yongkang WuDepartment of Physiology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Xingyu WangDepartment of Physiology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China.
Meng ZhangInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Daxue Road, Jinan, 250355, China.
Yongjun ChenInstitute of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Daxue Road, Jinan, 250355, China. chenyongjun@sdutcm.edu.cn.
Ying XuDepartment of Physiology, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, China. yingxu612@shutcm.edu.cn.ORCID http://orcid.org/0000-0003-3563-4233

Funding

Fellowship of China Postdoctoral Science Foundation 2024M761173Fellowship of China Postdoctoral Science Foundation 2024M762109National Natural Science Foundation of China 81973948National Natural Science Foundation of China 82174003National Natural Science Foundation of China 82405205Science and Technology Program of Guangdong 2018B030334001Shanghai Institute of Traditional Chinese Medicine for mental health SZB2024201
6 · The paper itself

Abstract

Anxiety occurs in the early stage of cognitive disorders, which can exacerbate cognitive impairment. However, the pathogenesis of this kind of anxiety remains unclear. In this study, we investigated anxiety-like behaviors in young adult presenilin 1/2 conditional double knockout (PS cDKO) mice, a model of progressive cognitive impairment, using behavioral tests and electrophysiological recordings. Disrupted excitatory/inhibitory (E/I) balance was observed in pyramidal neurons (PNs) of the ventral hippocampus (vHPC) CA1 (vCA1) region of PS cDKO mice. Meanwhile, PV + interneurons showed hypoexcitability, associated with increased outward K

Indexed as

AnxietyCognitive disorderExcitatory/inhibitory balanceKv1.1Parvalbumin-positive interneurons

Identifiers

PMID40563122
PMCPMC12199491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.