Evidence map›Paper›PMID 40563089›Full record

ArticleBMC oral health2025

Involvement of the gene encoding the collagen type II alpha 1 chain in mandibular mobility.

Bianca Cavalcante-Leão, João Armando Brancher, Fernanda Bertoli, Michelle Nascimento Meger, Luisa Helena Batista, Thais Vilalba, Maria Angélica Hueb de Menezes-Oliveira, Flares Baratto-Filho, Christian Kirschneck, Juliana Feltrin-Souza and 1 more

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Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Bianca Cavalcante-LeãoSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
João Armando BrancherPostgraduate Program in Cell and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil.
Fernanda BertoliPostgraduate Program in Cell and Molecular Biology, Federal University of Paraná, Curitiba, PR, Brazil.
Michelle Nascimento MegerSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
Luisa Helena BatistaSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
Thais VilalbaSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
Maria Angélica Hueb de Menezes-OliveiraDepartment of Biomaterials, University of Uberaba - UNIUBE, Uberaba, Minas Gerais, Brazil.
Flares Baratto-FilhoSchool of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.
Christian KirschneckDepartment of Orthodontics, University of Bonn, Medical Faculty, Welschnonnenstr. 17, Bonn, 53111, Germany.
Juliana Feltrin-SouzaDepartment of Stomatology, Federal University of Paraná, Curitiba, Paraná, Brazil.
Erika Calvano KüchlerDepartment of Orthodontics, University of Bonn, Medical Faculty, Welschnonnenstr. 17, Bonn, 53111, Germany. erika.kuchler@ukbonn.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are no studies investigating the role of COL2A1 genes for mandibular mobility. The aim of this study was investigate the association between mandible mobility with single nucleotide polymorphisms (SNPs) in gene encoding collagen type II alpha 1 chain (COL2A1).

methodsAdolescents age from 10 to 14 years old without restrictions in mandibular movement were evaluated. The mandibular mobility was recorded using rule. Genomic DNA was obtained from saliva and the SNPs in COL2A1 gene (rs1793953 and rs2276454) were genotyped by real time polymerase chain reactions. One-way ANOVA with Tukey's post-test was used to compare the mean values of the mandibular mobility among genotypes in the co-dominant model. A linear regression analysis was also performed.

results99 adolescents were included (53 boys and 46 girls). Gender and age were not associated with mandibular movements. For the rs1793953, unassisted opening, assisted opening and contralateral movements were statistically different among genotypes. The rs2276454 was associated with larger protrusive movements, in patients carrying TT genotype presented higher protrusion mean values than CT and TT individuals (p = 0.0046).

conclusionsOur findings suggest that genes may play an essential role for the normal variation in mandibular movement and SNPs rs1793953 and rs2276454 in COL2A1 may explain mandibular mobility variations.

Indexed as

Collagen Type IIMandibleRange of Motion, ArticularAdolescentChildFemaleGenotypeHumansMalePolymorphism, Single NucleotideCOL2A1 protein, humanCollagen Type IICollagen type II alpha 1 chainGeneticsMandibular movements

Identifiers

PMID40563089
PMCPMC12199490

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