Evidence map›Paper›PMID 40563087›Full record

ArticleBMC gastroenterology2025

Risk factors affecting the incidence of CMV infection in recipients after living donor liver transplantation.

Mostafa Attya Elfors, Magdy Galal Eldin Helmy, Hossam Eldin Abdelaziz Mahmoud, Maha Mohsen Hussein, Ahmed Mohamed Naguib, Mohamed Bahaa El Din Ahmed, Hosam Samir Ibrahim Elbaz, Mohamed Osama Aly Aly

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In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mostafa Attya ElforsDepartment of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt. mostafaalfors@med.asu.edu.eg.ORCID http://orcid.org/0009-0000-9578-8133
Magdy Galal Eldin HelmyDepartment of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hossam Eldin Abdelaziz MahmoudDepartment of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Maha Mohsen HusseinDepartment of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0000-0001-5903-1811
Ahmed Mohamed NaguibDepartment of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0009-0008-8681-2857
Mohamed Bahaa El Din AhmedDepartment of General Surgery and Liver Transplantation, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hosam Samir Ibrahim ElbazDepartment of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed Osama Aly AlyDepartment of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytomegalovirus (CMV), a common virus with double-stranded DNA, causes complications and occasional death post-liver transplantation. The pre-transplant donor's and recipient's serological status is the primary potential factor for CMV reactivation. Our research aimed to assess risk factors that predict the possibility of CMV infection in post-liver transplant patients.

methodsThis retrospective study included 194 adult patients with hepatitis C-related end-stage liver disease (ESLD) who received liver transplants at the Ain Shams Center for Organ Transplantation between January 2014 and December 2018. The data were collected and analyzed regarding demographics, lab results, surgery details, and post-transplant outcomes to determine the rate of post-transplant CMV infection and identify its risk factors.

resultsThe graft rejection was more common among recipients who developed CMV infection (31.8%) compared to those without infection (11.3%). CMV infection appeared to be more frequent among patients receiving cyclosporine-based immunosuppressive therapy. Recipients with higher Model for End-Stage Liver Disease (MELD) scores showed increased incidence of post-transplant CMV infection. CMV IgM seropositivity pre-transplant was associated with post-transplant CMV infection.

conclusionCyclosporine-based immunosuppressants, younger recipient age, a higher MELD score, and pre-transplant positive CMV IgM status were found to be risk factors associated with post-transplant CMV infection. CMV infection appeared to be associated with graft rejection.

Indexed as

Cytomegalovirus InfectionsEnd Stage Liver DiseaseLiver TransplantationPostoperative ComplicationsAdultAge FactorsCyclosporineCytomegalovirusFemaleGraft RejectionHumansImmunoglobulin MImmunosuppressive AgentsIncidenceLiving DonorsMaleCyclosporineImmunoglobulin MImmunosuppressive AgentsCytomegalovirusImmunosuppressionLiver transplantationRisk factors

Identifiers

PMID40563087
PMCPMC12188661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.