Evidence map›Paper›PMID 40563075›Full record

ReviewCancer metastasis reviews2025

Prospects and limitations of NK cell adoptive therapy in clinical applications.

Yamin Deng, Chen Wu, Jintong Na, Jing Tang, Simin Qin, Zhiyong Zhang, Liping Zhong

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer metastasis reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. A novel cultivation strategy to recover NK cell cytotoxicity.Frontiers in bioengineering and biotechnology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yamin Deng *State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Chen Wu *State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Jintong Na *State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Jing TangState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Simin QinState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Zhiyong ZhangState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, Guangxi, 530021, China. zhiyongzhang@yahoo.com.
Liping ZhongState Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Major New Drugs Innovation and Development, Guangxi Medical University, Nanning, Guangxi, 530021, China. zhongliping@gxmu.edu.cn.

Funding

Guangxi Natural Science Funds for Distinguished Young Scholars 2022GXNSFFA035026Guangxi Science and Technology Program Guike AB23026058National Natural Science Foundation of China Young Scientist Fund 82104654the Special Funds of the National Natural Science Foundation of China 82350106
6 · The paper itself

Abstract

During the last three decades, there has been substantial advancement in comprehending the chemical attributes and roles of natural killer (NK) cells, resulting in a growing interest in these cells. Simultaneously, the swift advancement of adoptive transfer therapy for immune cells, particularly the impressive achievements of autologous chimeric antigen receptor-T (CAR-T) cells in treating hematological malignant tumors, has fueled interest in using immune cells as a cancer treatment modality and opened the door for NK cell adoptive immunotherapy. NK cell-mediated immunotherapy has shown potential as a readily available, safe, and effective treatment for patients with leukemia. Moreover, clinical studies have demonstrated that NK cell adoptive immunotherapy shows efficacy in various solid tumors and hematologic malignancies, indicating a promising future for this therapeutic approach. This paper will provide an overview of NK cell adoptive therapy, focusing on current clinical trial results and the challenges associated with clinical applications.

Indexed as

Immunotherapy, AdoptiveKiller Cells, NaturalNeoplasmsAnimalsHumansReceptors, Chimeric AntigenReceptors, Chimeric AntigenAdoptive therapyClinical trailsGenetic manipulationNK cells

Identifiers

PMID40563075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.