Evidence map›Paper›PMID 40563048›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025

Clinical analysis of Mycoplasma pneumoniae pneumonia combined with adenovirus infection in children with lobar pneumonia.

Meiying Piao, Na Liu, Fanyang Meng, Hang Liang

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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  5. Building a diagnostic prediction model for severeFrontiers in public health · 2025
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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Meiying PiaoDepartment of Respiratory, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Na LiuDepartment of Respiratory, Children's Medical Center, The First Hospital of Jilin University, Changchun, China.
Fanyang MengDepartment of Radiology, The First Hospital of Jilin University, Changchun, China.
Hang LiangDepartment of Respiratory, Children's Medical Center, The First Hospital of Jilin University, Changchun, China. Lianghang@jlu.edu.cn.

Funding

Funding from Science and Technology Department of Jilin Province Grant No.20230204095YY
6 · The paper itself

Abstract

objectiveMycoplasma pneumoniae (MP) is a major pathogen that causes community-acquired pneumonia in children with a high rate of co-infection. Human adenovirus (HAdV) is a common co-infecting pathogen. This study aimed to analyze the clinical characteristics of children with lobar pneumonia caused by co-infection with MP and HAdV, and to investigate the correlation between the MP mutation sequence ratio (mutation depth/MP count) and HAdV sequence count with disease severity, thus providing evidence for clinical diagnosis and treatment.

methodsChildren with MP-infected lobar pneumonia hospitalized in the Department of Pediatric Respiratory Medicine at the First Hospital of Jilin University from September to November 2023 were enrolled in this study and divided into MP and MP + HAdV groups. Clinical manifestations, laboratory examinations, and treatments were compared between the two groups. Correlations of the MP mutation sequence ratio and HAdV sequence count with clinical manifestations, laboratory examinations, and treatments were analyzed.

resultsA total of 154 children with MP lobar pneumonia were included, with 96 cases in the MP group and 58 cases in the MP + HAdV group. The results showed that the MP + HAdV group had a longer total disease duration, fever duration, intravenous anti-MP drug administration duration, and systemic corticosteroid application duration, with a higher proportion of intravenous immunoglobulin use. The MP group had higher CRP levels and a higher incidence of pulmonary necrosis. After 10 days of treatment, the MP group showed better improvement in the pneumonia volume than the MP + HAdV group. There were no significant differences between the two groups in the length of hospital stay, peak fever, wheezing and rash, oxygen therapy proportion, or second-line anti-MP drug usage. No significant differences were observed between the two groups in the WBC, ESR, LDH, D-dimer, albumin, ALT, ferritin levels, incidence of atelectasis, pleural effusion, or bronchoscopy findings.

conclusionCo-infection with HAdV can exacerbate the condition of children with MP lobar pneumonia and increase treatment difficulty. Higher MP mutation sequence ratios are associated with more severe airway mucosal damage, and higher HAdV viral loads correlate with more severe disease.

Indexed as

Adenovirus Infections, HumanCoinfectionMycoplasma pneumoniaePneumonia, MycoplasmaAdenoviruses, HumanAnti-Bacterial AgentsChildChild, PreschoolCommunity-Acquired InfectionsFemaleHumansInfantMaleMutationAnti-Bacterial AgentsChildrenClinical featuresHuman adenovirusLobar pneumoniaMycoplasma pneumoniae

Identifiers

PMID40563048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.