Evidence map›Paper›PMID 40563034›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Pseudopapillary and micropapillary-like changes in classical renal angiomyolipoma: a multi-institutional series of 60 cases.

Elie Tannous, Deniz Baycelebi, Ankur R Sangoi, Richard R Pacheco, Mohammed A Alghamdi, Andrea R Lightle, Khaleel Al-Obaidy, Sean R Williamson, Zeliha Cetin, Dimitrios Korentzelos and 1 more

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Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Elie TannousDepartment of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Deniz BaycelebiDepartment of Pathology, Ondokuz Mayis University School of Medicine, Samsun, Türkiye.
Ankur R SangoiDepartment of Pathology, Stanford Health Care, Stanford, CA, USA.
Richard R PachecoDepartment of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Mohammed A AlghamdiDepartment of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Andrea R LightleDepartment of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Khaleel Al-ObaidyMcLaren Pathology Group, McLaren Health Care, Flint, MI, USA.
Sean R WilliamsonDepartment of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.
Zeliha CetinDepartment of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Dimitrios KorentzelosDepartment of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Mahmut AkgulDepartment of Pathology and Laboratory Medicine, Brigham and Women's Hospital, 75 Francis Street, Room AL.360E, Boston, MA, USA. makgul@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-0929-0940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudopapillary- and micropapillary-like changes in classical renal angiomyolipoma (AML) are underappreciated morphologic patterns that in some instances may cause diagnostic confusion with renal cell carcinoma or urothelial carcinoma. To further evaluate the incidence of these morphologies, a multi-institutional cohort of 60 patients with classical AML was retrospectively analyzed by genitourinary pathologists. Clinicopathologic features include tumor characteristics of fat assessment and extent of pseudopapillary/micropapillary-like changes were recorded. Chi-square test was conducted to determine associations with tumor subtype. Most cases were unilateral (56/60; 93%) and solitary (55/60; 92%), with a median tumor size of 3.1 cm (range: 0.25 - 19.0 cm). Pseudopapillary/micropapillary changes were identified in 19/60 cases (32%), significantly occurring more frequently in fat-poor AML (17/30; 57%) compared to non-fat-poor AML (2/30; 7%; p < 0.001). Pseudopapillary/micropapillary growth, mostly in mixed form, within tumors was 20% on average (range: 1 - 60%). No recurrence or tumor-related deaths were observed [44/60 patients; median follow-up = 11 months (range: 1- 96 months)]. Recognizing pseudopapillary/micropapillary features, particularly in fat-poor AML and in a biopsy setting, is critical to avoid misdiagnosis.

Indexed as

AngiomyolipomaKidney NeoplasmsAdultAgedAged, 80 and overCarcinoma, Renal CellDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRetrospective StudiesYoung AdultClassic angiomyolipomaKidneyMicropapillary-likePseudopapillary

Identifiers

PMID40563034

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