ReviewGeroScience2026
Osteoimmunology and aging - a frontier to explore.
Review in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Epigenetic reprogramming periosteum promotes aging critical segmental bone defect repair via methylation remodeling.Bioactive materials · 2026Article
- Mechanisms of the IL-33/ST2 Signaling Axis in Regulating Bone Metabolism.Biomolecules · 2026Review
- Immune cell senescence and chronic bone diseases: osteoimmune mechanisms and therapeutic perspectives.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Osteoimmunology is an interdisciplinary branch of immunology which studies the interplay of skeletal and immune systems. Both spatial and functional connections exist between the two systems, as most immune cells are generated in the bone marrow microenvironment, which facilitates the communication between the two systems. Moreover, immune cytokines such as RANKL (receptor activating Nf-kB ligand) and non-immune soluble mediators such as osteoprotegrin (OPG), made by immune and bone cells, respectively, interact to influence differentiation and activation of each other. The above interactions become of particular importance in the old age, when dysregulation of both systems yields changes affecting both length and quality of life. This perspective paper will outline both our current understanding as well as general gaps in knowledge, on geriatric osteoimmunology. We will also specifically address two highly prevalent diseases of aging, osteoarthritis and osteoporosis, as major sources of disability, loss of independence and increased morbidity and mortality in older adults, because cellular senescence appears to play a substantial pathogenetic role in both conditions, potentially opening new avenues for diagnosis and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.