Evidence map›Paper›PMID 40563005›Full record

ArticleMolecular neurobiology2025

PGRN Counteracts the Associations of Abnormal Tau Proteins with Neurodegeneration and Cognitive Decline in Non-demented Adults: A Longitudinal Study.

Yi-Fan Sun, Yan-Bing Liu, Chen-Chen Tan, Lan Tan, Wei Xu

Abstract read
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Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yi-Fan Sun *Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Donghai Middle Road, No.5, Qingdao, China.
Yan-Bing Liu *Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Donghai Middle Road, No.5, Qingdao, China.
Chen-Chen TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Donghai Middle Road, No.5, Qingdao, China.
Lan TanDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Donghai Middle Road, No.5, Qingdao, China.
Wei XuDepartment of Neurology, Qingdao Municipal Hospital, Qingdao University, Donghai Middle Road, No.5, Qingdao, China. dr_xuwei@qdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal tau proteins are characterized by accumulation of abnormally phosphorylated tau followed by irreversible loss of neurons. Progranulin (PGRN) is a secreted pleiotropic glycoprotein against the development of multiple neurodegenerative diseases. However, it remains unclear whether PGRN could modulate the relationships of abnormal tau proteins with cognition and neurodegeneration. A total of 606 non-demented participants were followed for 8 years and were annually assessed for cognition and brain volumes. Abnormal tau protein (TN) status was determined by cerebrospinal fluid (CSF) levels of P-tau

Indexed as

Cognition DisordersIntercellular Signaling Peptides and ProteinsNerve DegenerationNeurodegenerative Diseasestau ProteinsAgedAtrophyBrainFemaleHumansLongitudinal StudiesMaleMiddle AgedProgranulinsGRN protein, humanIntercellular Signaling Peptides and ProteinsProgranulinstau ProteinsAlzheimer’s diseaseCognitionInteractionNeurodegenerationPGRNTN pathology

Identifiers

PMID40563005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.