ReviewDrug delivery and translational research2026
Mucoadhesive nanofibers for ocular drug delivery: mechanisms, design strategies, and applications.
Review in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bridging the Lab-to-Clinic Gap in Intranasal Nanomaterial-Based Chemotherapy for Glioblastoma.Pharmaceutics · 2026Review
- Design and synthesis of natural antibacterial derivatives for ocular tuberculosis: a comprehensive review.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Delivering drugs effectively to the ocular surface is challenging due to rapid clearance mechanisms, including blinking, tear turnover, and protective barriers of the conjunctival and corneal epithelium. As a result, conventional options such as eye drops often fail to provide sustained therapeutic effects and require frequent dosing, leading to reduced patient compliance. Mucoadhesive nanofiber systems offer a promising solution by enhancing drug retention and enabling controlled release at the ocular surface. These nanofibers, produced primarily through electrospinning, provide a high surface area, tunable mechanical properties, and compatibility with mucoadhesive polymers, collectively improving drug bioavailability, extending residence times, and minimizing systemic side effects. This review comprehensively explores the fundamentals of mucoadhesion, including the structural and compositional characteristics of ocular mucosal surfaces and the molecular interactions essential for optimized drug delivery. It examines advanced strategies for incorporating mucoadhesive features into nanofibers, such as polymer blending, surface modification, and molecular imprinting, and assesses their influence on therapeutic outcomes. Finally, recent advancements and their potential for clinical translation are discussed. By presenting a thorough analysis of current techniques and emerging innovations, this review aims to guide researchers in developing next-generation mucoadhesive nanofiber platforms that improve therapeutic efficacy and patient compliance in ocular drug delivery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.