Evidence map›Paper›PMID 40562938›Full record

ArticleNature2025

The dynamics and geometry of choice in the premotor cortex.

Mikhail Genkin, Krishna V Shenoy, Chandramouli Chandrasekaran, Tatiana A Engel

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. The human language processing system straightens natural speech.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Integration of Memory and Sensory Information in Skilled Sequence Production.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  5. Article
  6. No Central Executive? Decision Formation Through Multi-Area Population Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Motor cortex flexibly deploys a high-dimensional repertoire of subskills.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mikhail GenkinCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0002-5476-7683
Krishna V ShenoyHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Chandramouli ChandrasekaranDepartment of Anatomy & Neurobiology, Boston University, Boston, MA, USA.ORCID 0000-0002-1711-590X
Tatiana A EngelCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. tatiana.engel@princeton.edu.ORCID 0000-0001-5842-9406

Funding

Multimodal Characterization of Prefrontal and Premotor Circuits Underlying Perceptual Decision Making in Therhesus MonkeyR01NS122969 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI, LUEBKE, JENNIFER I · 2021 to 2025
$3.1M
Linking Motor Cortex Activity and Movement in the Mouse Orofacial SystemR01NS121409 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Michael Nicholas Economo · 2022 to 2026
$2.1M
Multiscale computational frameworks for integrating large-scale cortical dynamics, connectivity, and behaviorRF1DA055666 · NIDA · PRINCETON UNIVERSITY · PI ENGEL, TATIANA · 2021 to 2021
$1.3M
Discovering dynamic computations from large-scale neural activity recordingsR01EB026949 · NIBIB · COLD SPRING HARBOR LABORATORY · PI ENGEL, TATIANA · 2018 to 2020
$1.3M
Organization and Dynamics of Premotor and Prefrontal Cortical Circuits Mediating Goal-Directed BehaviorR00NS092972 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI · 2018 to 2020
$747k
Graphical Processing Units and a Large-Memory Compute Node for Applications in Genomics, Neuroscience, and Structural BiologyS10OD028632 · OD · COLD SPRING HARBOR LABORATORY · PI SIEPEL, ADAM CHARLES · 2020 to 2020
$437k
Causal Roles of Dorsolateral Prefrontal and Dorsal Premotor Cortex in Perceptual Decision-MakingR21NS135361 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHANDRASEKARAN, CHANDRAMOULI, RUSHMORE, RICHARD JARRETT · 2023 to 2023
$437k
Organization and Dynamics of Premotor and Prefrontal Cortical Circuits Mediating Goal-Directed BehaviorK99NS092972 · NINDS · STANFORD UNIVERSITY · PI CHANDRASEKARAN, CHANDRAMOULI · 2015 to 2016
$175k
NIBIB NIH HHS R01 EB026949NIDA NIH HHS RF1 DA055666NIH HHS S10 OD028632NINDS NIH HHS K99 NS092972NINDS NIH HHS R00 NS092972NINDS NIH HHS R01 NS121409NINDS NIH HHS R01 NS122969NINDS NIH HHS R21 NS135361
6 · The paper itself

Abstract

The brain represents sensory variables in the coordinated activity of neural populations, in which tuning curves of single neurons define the geometry of the population code

Indexed as

Choice BehaviorModels, NeurologicalMotor CortexAction PotentialsAnimalsCognitionDecision MakingMacaca mulattaMaleNeurons

Identifiers

PMID40562938
PMCPMC12408350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.