ArticleNature2025
Mechanism of cytarabine-induced neurotoxicity.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Decoding cytarabine-induced damage in the prepubertal testis: A multi-omics atlas of ecosystem and inheritance.iScience · 2026Article
- Article
- Barettin Suppresses Pancreatic Ductal Adenocarcinoma Proliferation via Topoisomerase IIα Inhibition.Marine drugs · 2026Article
- Article
- Nucleotide salvage, genome instability, and potential therapeutic applications.Nucleic acids research · 2026Review
- Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase.PLoS pathogens · 2026Article
- The Influence of Music Therapy on the Mood State and Hope Level of Patients with Leukemia Complicated with Anxiety Disorder.Noise & healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Jia-Cheng Liu *Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Dongpeng Wang *Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-8272-1228
Elsa CallenLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Chuanyuan ChenLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-5279-9035
Santiago NoriegaLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0009-0002-5166-9858
Yafang ShangKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.
David SchürmannDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID 0000-0003-2904-1378
Yawei SongKey Laboratory of Multi-Cell Systems, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Gokul N RamadossGladstone Institutes, San Francisco, CA, USA.ORCID 0000-0002-7506-2711
Raj ChariGenome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-2216-313X
Nancy WongLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Yongge ZhaoLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0003-4466-2391
Yuan HeDepartment of Biophysics, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-1455-3963
Peter D AplanGenetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-5686-9969
Michael E WardNational Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.ORCID 0000-0002-5296-8051
Nathaniel HeintzLaboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-8874-8704
Anjana RaoLa Jolla Institute for Immunology, La Jolla, CA, USA.ORCID 0000-0002-1870-1775
Peter J McKinnonCenter for Pediatric Neurological Disease Research, St Jude Pediatric Translational Neuroscience Initiative, Department of Cell and Molecular Biology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-0485-3778
Keith W CaldecottGenome Damage and Stability Centre, University of Sussex, Brighton, UK.ORCID 0000-0003-4255-9016
Primo SchärDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID 0000-0003-1843-6147
Fei-Long MengKey Laboratory of RNA Innovation, Science and Engineering, Shanghai Academy of Natural Sciences (SANS), Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0003-0333-6872
Ferenc LivakLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.
Wei WuKey Laboratory of Multi-Cell Systems, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0001-5164-2765
André NussenzweigLaboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. andre_nussenzweig@nih.gov.ORCID 0000-0002-8952-7268
Funding
Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI WALTER J. CHAZIN · 2001 to 2026
$89.6MThe TET-DNMT-ASXL1-OGT axis: relevance to clonal hematopoiesis, heterochromatin integrity and cancerR35CA210043 · NCI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Anjana Rao · 2016 to 2026
$10.6MATM and DNA Damage in the Nervous SystemR01NS037956 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MCKINNON, PETER J · 1998 to 2022
$7.6MDNA REPAIRZ01BC010283 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 1998 to 2008
$2.9MGenome Stability in Glia & DiseaseR01NS123081 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PETER J MCKINNON · 2022 to 2026
$2.3MStructure and Mechanism of Non-Homologous End JoiningR01GM135651 · NIGMS · NORTHWESTERN UNIVERSITY · PI HE, YUAN · 2020 to 2024
$1.8MStructure and Mechanism of Eukaryotic Transcription RegulationR01GM144559 · NIGMS · NORTHWESTERN UNIVERSITY · PI HE, YUAN · 2022 to 2025
$1.4MStructure and mechanism of how cells read and repair the genomeR35GM158347 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Yuan He · 2025 to 2026
$1.2MRelationship between DNA damage detection and signalingZ01BC010959 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSENZWEIG, ANDRE A. · 2008 to 2008
$812kATM and DNA Damage in the Nervous SystemR56NS037956 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MCKINNON, PETER J · 2007 to 2007
$413kIntramural NIH HHS Z01 BC010283Intramural NIH HHS Z01 BC010959NCI NIH HHS HHSN261201500003INCI NIH HHS P01 CA092584NCI NIH HHS R35 CA210043NIGMS NIH HHS R01 GM135651NIGMS NIH HHS R01 GM144559NIGMS NIH HHS R35 GM158347NINDS NIH HHS R01 NS037956NINDS NIH HHS R01 NS123081NINDS NIH HHS R56 NS037956
Abstract
Postmitotic neurons have high levels of methylated cytosine and its oxidized intermediates such as 5-hydroxymethylcytosine
Indexed as
Cytarabine5-MethylcytosineAnimalsCytosineDeoxycytidineDioxygenasesDNA-Binding ProteinsDNA Breaks, Double-StrandedDNA Breaks, Single-StrandedDNA DemethylationDNA Ligase ATPDNA MethylationDNA RepairEpigenesis, GeneticFemaleGemcitabine5-hydroxymethylcytosine5-MethylcytosineCytarabineCytosineDeoxycytidineDioxygenasesDNA-Binding ProteinsDNA Ligase ATPGemcitabineHistonesProto-Oncogene ProteinsTet2 protein, mouseThymine DNA Glycosylase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.