Evidence map›Paper›PMID 40562895›Full record

ArticleClinical oral investigations2025

The effect of fluocinolone acetonide, ProRoot MTA and their combination on inflammation and odontogenic differentiation of inflamed human dental pulp cells.

Suphachart Chayawatto, Chatvadee Kornsuthisopon, Pairoj Linsuwanont

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Suphachart ChayawattoDepartment of Restorative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Chatvadee KornsuthisoponCenter of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Pairoj LinsuwanontDepartment of Restorative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. linspairoj@gmail.com.

Funding

Faculty of Dentistry, Chulalongkorn University DRF_67_004
6 · The paper itself

Abstract

objectivesTo compare the effect of fluocinolone acetonide (FA), mineral trioxide aggregate (MTA), and their combination on inflamed human dental pulp cells (HDPCs), focusing on cell viability, expression of inflammation and mineralisation-associated genes, and odontogenic differentiation.

methodsHDPCs were treated with 20 µg/mL lipopolysaccharide (LPS) alone or in combination with and 400 µM hydrogen peroxide (H

resultsHDPCs pretreated with LPS and H

conclusionFA exerted anti-inflammatory properties and promoted odontogenic differentiation under the inflammatory milieus of HDPCs in this in vitro study. CLINICAL RELEVANCE: Under the simulated inflammatory condition of HDPCs, this in vitro study suggests the potential benefit of FA for anti-inflammatory and mineralisation enhancing properties.

Indexed as

Aluminum CompoundsAnti-Inflammatory AgentsCalcium CompoundsDental PulpFluocinolone AcetonideOdontogenesisOxidesSilicatesCell DifferentiationCells, CulturedCell SurvivalDrug CombinationsHumansHydrogen PeroxideLipopolysaccharidesRoot Canal Filling MaterialsAluminum CompoundsAnti-Inflammatory AgentsCalcium CompoundsDrug CombinationsFluocinolone AcetonideHydrogen PeroxideLipopolysaccharidesmineral trioxide aggregateOxidesProRoot MTARoot Canal Filling MaterialsSilicatesFluocinolone acetonideHuman dental pulp cellsHydrogen peroxideLipopolysaccharideMineral trioxide aggregateVital pulp therapy

Identifiers

PMID40562895

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.