ArticleNature neuroscience2025
Fine-mapping genomic loci refines bipolar disorder risk genes.
Erratum issuedAbstract read
In one paragraph
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of methylome-wide associations with anxiety disorders.Translational psychiatry · 2026Pooled it
- Higher frequencies of CNV deletions in bipolar disorder among Chinese Population.Molecular psychiatry · 2026Article
- Genetic Associations with Temporal Modeling of Alzheimer's Disease Progression Supports a Novel Paradigm for Disease Risk.medRxiv : the preprint server for health sciences · 2026Article
- Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.Nature neuroscience · 2026Article
- Probing neuropsychiatric disorders through in vivo CRISPR screening.Current opinion in genetics & development · 2026Review
- Multivariate GWAS reveals shared genetic basis of common oral diseases.Frontiers in genetics · 2026Article
- 6PPD-quinone exposure and Alzheimer's disease: insights from integrative network pharmacology, transcriptomics, machine learning, and molecular docking.Open medicine (Warsaw, Poland) · 2026Article
- Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.medRxiv : the preprint server for health sciences · 2025Article
- Fine-mapping methods for complex traits: essential adaptations for samples of related individuals.Briefings in bioinformatics · 2025Article
- Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights.medRxiv : the preprint server for health sciences · 2025Article
- Inflammatory and Oxidative Biological Profiles in Mental Disorders: Perspectives on Diagnostics and Personalized Therapy.International journal of molecular sciences · 2025Review
- Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes.Molecular psychiatry · 2025Article
- SNP-associated differential methylation inEpigenomics · 2025Article
- Genomic and Transcriptomic Signatures of SETD1A Disruption in Human Excitatory Neuron Development and Psychiatric Disease Risk.bioRxiv : the preprint server for biology · 2025Article
- Polygenic scores and antidepressant treatment outcomes in major depression: a critical integrative review.Neuroscience applied · 2025Article
- A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping.Nature communications · 2024Article
- Molecular Modeling and In Vitro Functional Analysis of the RGS12 PDZ Domain Variant Associated with High-Penetrance Familial Bipolar Disorder.International journal of molecular sciences · 2024Article
Corrections and comments
- Erratum issued
- Update of
Authors and funding
133 authors.
Maria KorominaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. maria.koromina@mssm.edu.ORCID http://orcid.org/0000-0001-8843-082X
Ashvin RaviDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Georgia PanagiotaropoulouDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
Brian M SchilderDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0001-5949-2191
Jack HumphreyDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0002-6274-6620
Alice BraunDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
Tim BigdeliSUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Chris ChatzinakosSUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Brandon J CoombesDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Jaeyoung KimDepartment of Digital Health, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-6983-7907
Xiaoxi LiuLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-1933-8613
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-6452-4095
Kevin S O'ConnellDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Mark J AdamsDivision of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3599-6018
Rolf AdolfssonDepartment of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden.ORCID http://orcid.org/0000-0001-9785-8473
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.ORCID http://orcid.org/0000-0001-9544-3944
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1688-6697
Till F M AndlauerDepartment of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2917-5889
Ole A AndreassenDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Anastasia AntoniouSecond Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Susanne BengesserMedical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Joanna BiernackaDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9350-4440
Michael BoehnkeCenter for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6442-7754
Rosa BoschInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.ORCID http://orcid.org/0000-0002-7596-183X
Murray J CairnsUniversity of Newcastle, Newcastle, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2490-2538
Vaughan J CarrSchool of Clinical Medicine, Discipline of Psychiatry and Mental Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-8907-5804
Miquel CasasInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.
Stanley CattsUniversity of Queensland, Brisbane, Queensland, Australia.
Sven CichonDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Aiden CorvinNeuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0001-6717-4089
Nicholas CraddockCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Konstantinos DafnasSecond Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Nina DalknerMedical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Franziska DegenhardtInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Arianna Di FlorioCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Dimitris DikeosSecond Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Frederike Tabea FellendorfMedical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Panagiotis FerentinosSecond Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.ORCID http://orcid.org/0000-0001-8531-5623
Andreas J ForstnerInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
Liz FortyCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-4349-8414
Mark FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6997-4215
Janice M FullertonNeuroscience Research Australia, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-4014-4490
Micha GawlikDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Ian R GizerDepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Katherine Gordon-SmithPsychological Medicine, University of Worcester, Worcester, UK.
Melissa J GreenNeuroscience Research Australia, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9361-4874
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
José Guzman-ParraMental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.ORCID http://orcid.org/0000-0002-1463-6435
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.ORCID http://orcid.org/0000-0001-6541-3795
Frans HenskensUniversity of Newcastle, Newcastle, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2358-5630
Jan HillertDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Assen V JablenskyUniversity of Western Australia, Nedlands, Western Australia, Australia.
Lisa JonesPsychological Medicine, University of Worcester, Worcester, UK.ORCID http://orcid.org/0000-0002-5122-8334
Ian JonesCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0001-5821-5889
Lina JonssonInstitute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
John R KelsoeDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-3013-2333
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-2514-2625
George KirovCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Manolis KogevinasISGlobal, Barcelona, Spain.
Mikael LandénInstitute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-4496-6451
Marion LeboyerUniversity of Paris Est Créteil, INSERM, IMRB, Translatiol Neuropsychiatry, Créteil, France.ORCID http://orcid.org/0000-0001-5473-3697
Melanie LengerMedical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Jolanta LissowskaCancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Christine LochnerSA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa.ORCID http://orcid.org/0000-0002-4766-3704
Carmel LoughlandUniversity of Newcastle, Newcastle, New South Wales, Australia.
Donald J MacIntyreDivision of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6963-1335
Nicholas G MartinGenetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Eirini MaratouMedical School, Clinical Biochemistry Laboratory, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Carol A MathewsDepartment of Psychiatry and Genetics Institute, University of Florida, Gainesville, FL, USA.
Fermin MayoralMental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Málaga, Spain.
Susan L McElroyResearch Institute, Lindner Center of HOPE, Mason, OH, USA.
Nathaniel W McGregorSystems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa.ORCID http://orcid.org/0000-0001-7195-4993
Andrew McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Andrew McQuillinDivision of Psychiatry, University College London, London, UK.ORCID http://orcid.org/0000-0003-1567-2240
Patricia MichieUniversity of Newcastle, Newcastle, New South Wales, Australia.ORCID http://orcid.org/0000-0002-4169-8519
Philip B MitchellDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
Paraskevi MoutsatsouMedical School, Clinical Biochemistry Laboratory, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Bryan MowryUniversity of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-4115-5645
Bertram Müller-MyhsokDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Richard M MyersHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.ORCID http://orcid.org/0000-0001-9701-676X
Igor NenadićDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.ORCID http://orcid.org/0000-0002-0749-7473
Caroline M NievergeltDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Markus M NöthenInstitute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0002-8770-2464
John NurnbergerStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Michael O 'DonovanCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0001-7073-2379
Claire O 'DonovanDepartment of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Roel A OphoffCenter for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8287-6457
Michael J OwenCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Christos PantelisDepartment of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-9565-0238
Carlos PatoInstitute for Genomic Health, SUNY Downstate Medical Center, College of Medicine, Brooklyn, NY, USA.
Michele T PatoInstitute for Genomic Health, SUNY Downstate Medical Center, College of Medicine, Brooklyn, NY, USA.
George P PatrinosDepartment of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, University of Patras School of Health Sciences, Patras, Greece.
Joanna M PawlakDepartment of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Roy H PerlisPsychiatry, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5862-6757
Evgenia PorichiSecond Department of Psychiatry, Attikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7582-2365
Josep Antoni Ramos-QuirogaInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.ORCID http://orcid.org/0000-0003-1622-0350
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.ORCID http://orcid.org/0000-0002-0992-634X
Eva Z ReininghausMedical University of Graz, Division of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
Marta RibasésInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.ORCID http://orcid.org/0000-0003-1039-1116
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5236-6149
Ulrich SchallUniversity of Newcastle, Newcastle, New South Wales, Australia.
Peter R SchofieldDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Thomas G SchulzeDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0001-6624-2975
Laura ScottCenter for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4886-5084
Rodney J ScottUniversity of Newcastle, Newcastle, New South Wales, Australia.ORCID http://orcid.org/0000-0001-7724-3404
Alessandro SerrettiDepartment of Medicine and Surgery, Kore University of Enna, Enna, Italy.ORCID http://orcid.org/0000-0003-4363-3759
Jordan W SmollerStanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
Beata ŚwiątkowskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
Maria Soler ArtigasInstituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.ORCID http://orcid.org/0000-0002-3213-1107
Dan J SteinSAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-1080-4339
Claudio TomaNeuroscience Research Australia, Sydney, New South Wales, Australia.
Paul TooneyUniversity of Newcastle, Newcastle, New South Wales, Australia.
Marquis P VawterFunctional Genomics Laboratory, School of Medicine, University of California Irvine, Irvine, CA, USA.
Eduard VietaClinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
John B VincentCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-0692-2519
Irwin D WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6862-1837
Cynthia Shannon WeickertDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
Thomas WeickertDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1571-1468
Kyung Sue HongDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.
Masashi IkedaDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.ORCID http://orcid.org/0000-0001-6237-2449
Nakao IwataDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.ORCID http://orcid.org/0000-0003-3189-6076
Hong-Hee WonDepartment of Digital Health, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-5719-0552
Howard J EdenbergBiochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-0344-9690
Stephan RipkeDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.ORCID http://orcid.org/0000-0003-3622-835X
Towfique RajDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID http://orcid.org/0000-0002-9355-5704
Jonathan R I ColemanSocial, Genetic and Developmental Psychiatry Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0002-6759-0944
Niamh MullinsDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA. niamh.mullins@mssm.edu.ORCID http://orcid.org/0000-0001-8021-839X
Funding
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Carolyn Wei Zhu · 2020 to 2026
$31.0MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M3/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124839 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANDREASSEN, OLE A, HUCKINS, LAURA MARIANNE · 2021 to 2025
$2.0MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MNIA NIH HHS P30 AG066514NIH HHS S10 OD018522NIH HHS S10 OD026880NIMH NIH HHS R01 MH124839
Abstract
Bipolar disorder is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 bipolar disorder risk loci, the causal SNPs and genes within these loci remain unknown. We applied a suite of statistical and functional fine-mapping methods to these loci and prioritized 17 likely causal SNPs for bipolar disorder. We mapped these SNPs to genes and investigated their likely functional consequences by integrating variant annotations, brain cell-type epigenomic annotations, brain quantitative trait loci and results from rare variant exome sequencing in bipolar disorder. Convergent lines of evidence supported the roles of genes involved in neurotransmission and neurodevelopment, including SCN2A, TRANK1, DCLK3, INSYN2B, SYNE1, THSD7A, CACNA1B, TUBBP5, FKBP2, RASGRP1, FURIN, FES, MED24 and THRA among others in bipolar disorder. These represent promising candidates for functional experiments to understand biological mechanisms and therapeutic potential. Additionally, we demonstrated that fine-mapping effect sizes can improve performance of bipolar disorder polygenic risk scores across diverse populations and present a high-throughput fine-mapping pipeline.
Indexed as
Bipolar DisorderChromosome MappingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMultifactorial InheritancePolymorphism, Single NucleotideQuantitative Trait Loci
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