Evidence map›Paper›PMID 40562882›Full record

Trial reportJournal of general internal medicine2025

Adopting Self-Measured Blood Pressure Monitoring Among Underserved Communities (ASPIRE): A Pilot Randomized Controlled Trial.

Rasha Khatib, Nicole Glowacki, Iridian Guzman, Osondi Ozoani, John Brill, Julie C Lauffenburger, Alex Biskis, Melanie Gordon

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of general internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06175793 (ASPIRE), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06175793 nacompletednot on this map

ASPIRE: Adapting Self-Blood Pressure Monitoring to Reduce Health Disparities

TypeinterventionalSponsorWake Forest University Health SciencesRan2024 to 2024Enrolled50ConditionsHypertensionArmsASPIRE Intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rasha KhatibAdvocate Aurora Research Institute, Advocate Health, Milwaukee, WI, USA. rasha.alkhatib@aah.org.
Nicole GlowackiAdvocate Aurora Research Institute, Advocate Health, Milwaukee, WI, USA.ORCID 0000-0001-6975-268X
Iridian GuzmanAdvocate Aurora Research Institute, Advocate Health, Milwaukee, WI, USA.
Osondi OzoaniAdvocate Aurora Research Institute, Advocate Health, Milwaukee, WI, USA.
John BrillEnterprise Population Health, Advocate Health, Milwaukee, WI, USA.
Julie C LauffenburgerCenter for Healthcare Delivery Sciences (C4HDS), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Alex BiskisAdvocate Aurora Research Institute, Advocate Health, Milwaukee, WI, USA.
Melanie GordonAdvocate Christ Medical Center, Advocate Health, Oak Lawn, IL, USA.

Funding

The Institute for Translational MedicineUL1TR002389 · NCATS · UNIVERSITY OF CHICAGO · PI Joshua J Jacobs, DAVID O MELTZER · 2017 to 2026
$71.6M
NCATS NIH HHS 5UL1TR002389-06NCATS NIH HHS UL1 TR002389
6 · The paper itself

Abstract

backgroundAddressing barriers to self-measured blood pressure (SMBP) engagement through tailored implementation strategies is critical for improving hypertension-related outcomes.

objectiveTo evaluate the feasibility of implementing the ASPIRE Clinical Integration Package, a multifaceted intervention designed to support SMBP adoption and engagement in under-resourced primary care settings.

designThis randomized trial was conducted in 2024 at one large primary care clinic serving racially and ethnically diverse populations.

participantsPatients were eligible if they had hypertension, were prescribed ≥1 blood pressure-lowering medication, and presented to the clinic with an elevated blood pressure reading. APPROACH: Patients were randomized to receive a free SMBP device (control; n=25) or a free SMBP device and the ASPIRE Clinical Integration Package (intervention; n=25) which included 6 components; 1. Cuff sizing, 2. Training on accurate readings, 3. ASPIRE log, 4. Reminders/support for sharing readings, 5. Social needs screening, 6. Clinic workflow for SMBP documentation. The primary outcomes included feasibility metrics (referral, recruitment, and retention) and fidelity described in terms of the proportion of patients who received each of the 6 ASPIRE components. Secondary outcomes included SMBP engagement (1+ reading documented in the electronic health record) and change in systolic blood pressure. KEY

resultsIn total, 50 patients were randomized and included in analyses. Referral (60.0%), recruitment (60.2%), and retention (90.0%) targets were met. Fidelity evaluation revealed that 100% of patients received components 1 - 4, 96% and 93% received components 5 and 6, respectively. At 6-months the difference in SMBP engagement was 52.0% (95% confidence interval [CI] 29.3%-74.7%) favoring the intervention arm, and the difference in change in systolic blood pressure was -11.9mmHg (95% CI -21.7, -2.1) favoring the intervention arm.

conclusionsThe ASPIRE Clinical Integration Package demonstrates feasibility and acceptability in promoting SMBP adoption in under-resourced primary care settings. These findings lay the groundwork for a larger trial to assess effectiveness in improving hypertension control and reducing disparities.

trial registrationClinicalTrials.gov Identifier NCT06175793.

Indexed as

Blood Pressure Monitoring, AmbulatoryHypertensionMedically Underserved AreaAdultAgedBlood PressureFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsPrimary Health CareHypertensionImplementation scienceSelf-blood pressure monitoring (SMBP)Social needs

Identifiers

PMID40562882
PMCPMC12686236

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.