Evidence map›Paper›PMID 40562869›Full record

ArticleCellular & molecular immunology2025

Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic viruses.

Yeon Jeong Yoo, Suhyeon Kim, Asha Wickramasinghe, Jaemoo Kim, JuA Song, Young-Il Kim, Juryeon Gil, Young-Woock Noh, Min-Ho Lee, Sang-Seok Oh and 5 more

Erratum issuedAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Yeon Jeong Yoo *SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Science and Technology, Department of Nano Engineering, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, Republic of Korea.
Suhyeon Kim *SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Science and Technology, Department of Nano Engineering, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, Republic of Korea.
Asha Wickramasinghe *College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.ORCID 0009-0009-3241-7453
Jaemoo Kim *Center for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea.ORCID 0009-0003-4216-8397
JuA SongSKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Science and Technology, Department of Nano Engineering, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, Republic of Korea.
Young-Il KimCenter for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea.ORCID 0000-0002-0145-7382
Juryeon GilCenter for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea.ORCID 0000-0002-9415-0688
Young-Woock NohNew Drug Development Center, Osong Medical Innovation Foundation, Cheongju, Republic of Korea.
Min-Ho LeeNew Drug Development Center, Osong Medical Innovation Foundation, Cheongju, Republic of Korea.
Sang-Seok OhNew Drug Development Center, Osong Medical Innovation Foundation, Cheongju, Republic of Korea.
Myeong-Mi LeeNew Drug Development Center, Osong Medical Innovation Foundation, Cheongju, Republic of Korea.
Yebin SeongCollege of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Jong-Soo LeeCollege of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea. jongsool@cnu.ac.kr.ORCID 0000-0001-5119-0711
Young Ki ChoiCenter for Study of Emerging and Re-emerging Viruses, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon, Republic of Korea. choiki55@ibs.re.kr.ORCID 0000-0002-0872-0147
Yong Taik LimSKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Science and Technology, Department of Nano Engineering, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, Suwon, Republic of Korea. yongtaik@skku.edu.ORCID 0000-0001-5558-5526

Funding

Institute for Basic Science (IBS) IBS-R801-D1National Research Foundation of Korea (NRF) 00218648National Research Foundation of Korea (NRF) 2020R1A2C300688National Research Foundation of Korea (NRF) 2021R1A6A1A03045495
6 · The paper itself

Abstract

The demand for safe vaccines that ensure long-term and broad protection against multiple viral variants has dramatically increased after the emergence of catastrophic infectious diseases such as COVID-19. To ensure long-term and broad protection against heterologous virus variants, antigen-specific polyfunctional T cells should be orchestrated with the activation of follicular helper T (T

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineCOVID-19COVID-19 VaccinesImmunomodulationSARS-CoV-2Toll-Like Receptor 7Toll-Like Receptor 8AnimalsAntigen-Presenting CellsB-LymphocytesEmulsionsFemaleHumansMicePandemicsAdjuvants, ImmunologicAdjuvants, VaccineCOVID-19 VaccinesEmulsionsToll-Like Receptor 7Toll-Like Receptor 8Dynamic immunomodulationHeterologous virusesNanoemulsionTLR7/8 agonistVaccine adjuvant

Identifiers

PMID40562869
PMCPMC12398497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.