ArticleNature biomedical engineering2025
Self-organization of sinusoidal vessels in pluripotent stem cell-derived human liver bud organoids.
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Article in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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Who cites it
26 citing papers in PubMed.
- Reverse bioengineering of the liver: developmental principles for next-generation liver-on-a-chip systems.Communications biology · 2026Review
- Self-Organized Vascularized Human Liver Spheroids: Serum-Free Culture Conditions and Use as Tissue Building Blocks.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Pre-Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advances in vascularized organoids.Chinese medical journal · 2026Review
- Leveraging IGF signaling to improve the spatial organization and regenerative potential of iPSC-derived vascularized liver organoids.Science advances · 2026Article
- Liver organoids for chemical risk assessment: biological fidelity, standardization, and context-of-use frameworks.Archives of pharmacal research · 2026Review
- Synthetic developmental engineering of human liver organogenesis.Development (Cambridge, England) · 2026Review
- [Research advances on the application of skin appendage organoids in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Construction of liver organoid models by hepatobiliary differentiation from human induced pluripotent stem cells: state of the art, challenges and improving strategies.Stem cell research & therapy · 2026Review
- Mesoscale maladaptation in disease organoids.Disease models & mechanisms · 2026Article
- Advances in In Vitro Vascularization of Engineered Tissues: From Microvessel Formation to Hepatic Tissue Integration.Regenerative therapy · 2026Article
- Kidney organoid vascularization: current advancements in the field.Regenerative therapy · 2026Article
- Organoids in Pediatric Congenital Hepatobiliary Diseases: Current Status and Progress in Clinical Translational Research.Biomedicines · 2026Review
- Organoids: generation strategies, applications, and future challenges.Stem cell research & therapy · 2026Review
- Paracrine Factor Local Gradient-Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion-Induced Proliferation.Advanced healthcare materials · 2026Article
- Article
- Endothelial Cell Therapy for the Acute and Chronic Liver Disease.Seminars in liver disease · 2026Review
- A vascularized liver microphysiological system captures key features of hepatic insulin resistance and monocyte infiltration.Nature communications · 2026Article
- Article
- Advances in liver and pancreas organoids: how far we have come and where we go next.Nature reviews. Gastroenterology & hepatology · 2026Review
Corrections and comments
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Authors and funding
17 authors.
Norikazu SaikiHuman Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0830-4848
Yasunori NioOrganoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan.
Yosuke YoneyamaHuman Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo, Japan.
Shuntaro KawamuraHuman Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo, Japan.
Kentaro IwasawaDivision of Gastroenterology, Hepatology and Nutrition and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Eri KawakamiOrganoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan.
Kohei ArakiOrganoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan.
Junko FukumuraOrganoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan.
Tsuyoshi SakairiOrganoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan.
Tamaki KonoOrganoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan.
Rio OhmuraHuman Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo, Japan.
Masaru KoidoOrganoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan.
Masaaki FunataOrganoid Medicine Project, T-CiRA Joint Program, Fujisawa, Japan.
Wendy L ThompsonDivision of Gastroenterology, Hepatology and Nutrition and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Pamela Cruz-EncarnacionDepartment of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ya-Wen ChenDepartment of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Takanori TakebeHuman Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo, Yushima, Bunkyo-ku, Tokyo, Japan. Takanori.Takebe@cchmc.org.ORCID http://orcid.org/0000-0002-6989-3041
Funding
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4MModeling diabetes using an integrated plate systemUH3DK119982 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE, MOO-YEAL, WELLS, JAMES M · 2020 to 2022
$5.4MEngineering multi-organs in a dishDP2DK128799 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI TAKEBE, TAKANORI · 2020 to 2020
$2.3MModeling diabetes using an integrated plate systemUG3DK119982 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE, MOO-YEAL, WELLS, JAMES M · 2018 to 2019
$1.7MOrganoid-guided Precision Hepatology for SteatohepatitisR01DK135478 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Takanori Takebe · 2024 to 2026
$1.6MNIDDK NIH HHS DP2 DK128799NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK135478NIDDK NIH HHS UG3 DK119982NIDDK NIH HHS UH3 DK119982
Abstract
The induction of tissue-specific vessels in in vitro living tissue systems remains challenging. Here, we directly differentiated human pluripotent stem cells into CD32b
Indexed as
LiverOrganoidsPluripotent Stem CellsAnimalsCell DifferentiationEndothelial CellsHepatocytesHumansInduced Pluripotent Stem CellsMiceNeovascularization, Physiologic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.