Evidence map›Paper›PMID 40562850›Full record

ArticleWorld journal of urology2025

Does a kidney stone culture make sense? The findings of microbiological cultures of kidney stones and correlation with stone composition, preoperative urine testing and postoperative SIRS.

Hugo W Schuil, J van de Kamp, T R de Weijer, E P M van Elzakker, J Baard, A C Bouma-Houwert, M M E L Henderickx, C A Goossens-Laan, J A van der Spruit, R J A van Moorselaar and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Hugo W Schuil *Department of Urology, Amsterdam UMC, University of Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands. h.w.schuil@amsterdamumc.nl.
J van de Kamp *Department of Urology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
T R de WeijerDepartment of Urology, Alrijne Hospital, Leiderdorp, The Netherlands.
E P M van ElzakkerDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC, Amsterdam, The Netherlands.
J BaardDepartment of Urology, Amsterdam UMC, University of Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
A C Bouma-HouwertDepartment of Urology, Amsterdam UMC, University of Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
M M E L HenderickxDepartment of Urology, Amsterdam UMC, University of Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
C A Goossens-LaanDepartment of Urology, Alrijne Hospital, Leiderdorp, The Netherlands.
J A van der SpruitDepartment of Urology, Alrijne Hospital, Leiderdorp, The Netherlands.
R J A van MoorselaarCancer Center Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
H P BeerlageDepartment of Urology, Amsterdam UMC, University of Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
B M A SchoutDepartment of Urology, Alrijne Hospital, Leiderdorp, The Netherlands.
G M KamphuisDepartment of Urology, Amsterdam UMC, University of Amsterdam, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe study investigates the results of kidney stone cultures and its correlation with preoperative urine tests, stone composition and postoperative systemic inflammatory response syndrome (SIRS) in patients undergoing percutaneous nephrolithotomy (PCNL).

methodsData from 338 PCNL procedures performed between January 2018 and September 2023 at two centers in the Netherlands were included for analysis. Preoperative urine tests, kidney stone analysis and the outcome of kidney stone cultures were evaluated in addition to general patient characteristics and surgical information. Preoperative urine tests and stone cultures were concordant if they were both negative or both positive with the same microorganism. Multivariable logistic regression evaluated factors associated with positive stone cultures and their relationship to postoperative SIRS.

resultsStone cultures were positive in 43% of cases and were concordant with preoperative urine tests in 66% of cases. Stone culture results identified 33 different microorganisms, extending beyond urease-positive bacteria: most commonly found were Enterococcus faecalis, Escherichia coli, and Proteus mirabilis. Positive stone cultures were found across all types of stone composition. Positive stone cultures were significantly associated with postoperative SIRS (OR 3.12, 95% CI 1.01-9.65) and a positive preoperative urine test was not (OR 1.60, 95% CI 0.56-4.53).

conclusionStone cultures provide additional microbiological insights to preoperative urine testing. All types of stone composition can be associated with positive stone cultures, questioning the current thinking of infection vs. non-infection stones.

Indexed as

Kidney CalculiNephrolithotomy, PercutaneousPostoperative ComplicationsSystemic Inflammatory Response SyndromeAdultAgedFemaleHumansMaleMiddle AgedPreoperative CarePreoperative PeriodRetrospective StudiesUrinalysisInfectious complicationsKidney stone culturesPercutaneous nephrolithotomyStone compositionUrolithiasis

Identifiers

PMID40562850
PMCPMC12198257

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.