Evidence map›Paper›PMID 40562835›Full record

ArticleNature communications2025

Enhancing autophagy by redox regulation extends lifespan in Drosophila.

Claudia Lennicke, Ivana Bjedov, Sebastian Grönke, Katja E Menger, Andrew M James, Jorge Iván Castillo-Quan, Lucie A G van Leeuwen, Andrea Foley, Marcela Buricova, Jennifer Adcott and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Proteoforms as the true units of physiological function.European journal of applied physiology · 2026
    Review
  5. PLETHORA-autophagy axis activates organ regeneration through ROS modulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Claudia LennickeMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID http://orcid.org/0009-0008-5304-5145
Ivana BjedovUCL Cancer Institute, London, UK.
Sebastian GrönkeMax Planck Institute for Biology of Ageing, Cologne, Germany.ORCID http://orcid.org/0000-0002-1539-5346
Katja E MengerMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-6972-7326
Andrew M JamesMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0002-0515-9649
Jorge Iván Castillo-QuanInstitute of Healthy Ageing and GEE, University College London, London, UK.ORCID http://orcid.org/0000-0002-6324-2854
Lucie A G van LeeuwenMRC Laboratory of Medical Sciences (LMS), London, UK.
Andrea FoleyMRC Laboratory of Medical Sciences (LMS), London, UK.
Marcela BuricovaMRC Laboratory of Medical Sciences (LMS), London, UK.
Jennifer AdcottInstitute of Healthy Ageing and GEE, University College London, London, UK.
Alex MontoyaMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID http://orcid.org/0000-0002-6501-883X
Holger B KramerMRC Laboratory of Medical Sciences (LMS), London, UK.ORCID http://orcid.org/0000-0002-6400-0945
Pavel V ShliahaMRC Laboratory of Medical Sciences (LMS), London, UK.
Angela LoganMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Filipe CabreiroInstitute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK.ORCID http://orcid.org/0000-0002-3696-4843
Michael P MurphyMRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.ORCID http://orcid.org/0000-0003-1115-9618
Linda PartridgeMax Planck Institute for Biology of Ageing, Cologne, Germany. linda.partridge@ucl.ac.uk.ORCID http://orcid.org/0000-0001-9615-0094
Helena M CocheméMRC Laboratory of Medical Sciences (LMS), London, UK. helena.cocheme@lms.mrc.ac.uk.ORCID http://orcid.org/0000-0001-8637-0042

Funding

Wellcome Trust
6 · The paper itself

Abstract

Dysregulation of redox homeostasis is implicated in the ageing process and the pathology of age-related diseases. To study redox signalling by H

Indexed as

AutophagyDrosophila melanogasterLongevityAgingAnimalsAutophagy-Related ProteinsCatalaseDrosophilaDrosophila ProteinsFemaleHydrogen PeroxideOxidation-ReductionOxidative StressAutophagy-Related ProteinsCatalaseDrosophila ProteinsHydrogen Peroxide

Identifiers

PMID40562835
PMCPMC12198390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.