Observational studyPediatric research2026
Association between early fluid overload and clinical outcomes in a pediatric ICU.
Observational study in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The ROSE framework for fluid therapy in critically ill pediatric patients.Anaesthesiology intensive therapy · 2026Article
- Reassessing fluid creep: early targets for intervention in the PICU.Pediatric research · 2026Article
- Fluid Creep as an Independent Predictor of Fluid Overload and Mortality in Critically Ill Patients: A Cohort Study.Life (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluid overload (FO) during acute critical illness may affect outcomes. This study aimed to describe the incidence and contributors to cumulative FO 48 hours after pediatric MSICU admission and assess its association with clinical outcomes.
methodsA Retrospective observational cohort study was conducted of all Children 0-18 years old admitted from 2017-2022 with ICU stays >48 hours in the MSICU in an academic quaternary children's hospital. FO percentages, composition of fluid associated with FO at 48 hours was assessed and correlated with clinical outcomes.
resultsOf 3013 patients, 19% had severe FO (>10%). Patients with severe FO were younger. Maintenance IVF was highest in severe FO compared to moderate (5-10%) and mild (<5%) FO groups (122.0 vs. 104.0 vs. 74.0 mL/kg, P < 0.001). Total fluid intake at 48 hours exceeded estimated requirements across all groups. After adjusting for confounders, moderate and severe FO were associated with increased ICU length of stay (RR 1.22, RR 1.25, P < 0.001). Severe FO also increased acute kidney injury (AKI) odds (OR = 1.43, P = 0.016) and reduced ventilator-free days at day 28 (VFD28) (OR = 0.58, P < 0.001).
conclusionSevere FO at 48 hours was linked to increased ICU LOS, AKI incidence, and fewer VFD28. FO is driven by multiple modifiable subtypes, especially after the first 24 hours. Further studies should explore interventions to reduce FO and improve outcomes. IMPACT: Early FO at 48 h remains a prevalent problem in a mixed medical-surgical ICU and is linked to worse clinical outcomes. Severe FO was associated with younger age, lower body weight, and severity of illness in our cohort. The median total fluid intake at 48 h exceeded the estimated requirements in patients with any FO. We have identified specific fluid types that may be amenable to intervention to mitigate FO.
Indexed as
Identifiers
40562800What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.