Evidence map›Paper›PMID 40562789›Full record

ArticleLeukemia2025

Richter transformation in diffuse large B-cell lymphoma in patients with chronic lymphocytic leukemia receiving ibrutinib: risk factors and outcomes.

Sara Pepe, Candida Vitale, Diana Giannarelli, Andrea Visentin, Alessandro Sanna, Anna Maria Frustaci, Jacopo Olivieri, Francesca Maria Quaglia, Alessandro Gozzetti, Paolo Sportoletti and 22 more

Abstract read
In one paragraph

Article in Leukemia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Sara Pepe *Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
Candida Vitale *Department of Molecular Biotechnology and Health Sciences, University of Torino and Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.ORCID 0000-0002-2592-8724
Diana Giannarelli *Design and Analysis of Clinical Trials Unit, Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Andrea VisentinHematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padova, Italy.ORCID 0000-0003-0271-7200
Alessandro SannaHematology Unit, Department of Oncology, Azienda Ospedaliera Universitaria Careggi, Florence, Italy.
Anna Maria FrustaciASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Jacopo OlivieriASU Friuli Centrale, Unit of Hematology, Udine, Italy.
Francesca Maria QuagliaHematology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.ORCID 0000-0003-4347-3775
Alessandro GozzettiDepartment of Medicine, Surgery and Neurosciences, University of Siena, Policlinico S. Maria alle Scotte, Siena, Italy.ORCID 0000-0003-0769-6891
Paolo SportolettiInstitute of Hematology and Center for Hemato-Oncology Research, University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy.ORCID 0000-0002-5630-9862
Roberta MurruHematology and Stem Cell Transplantation Unit, Ospedale Oncologico A. Businco, ARNAS G. Brotzu", Cagliari, Italy.
Idanna InnocentiFondazione Policlinico Universitario A. Gemelli -Università Cattolica del Sacro Cuore, Milan, Italy.
Gianluigi RedaFondazione IRCCS Cà Granda Ospedale Maggiore Policlinico of Milan, Milano, Italy.
Livio PupoEmatologia, Dipartimento di Biomedicina e Prevenzione, Università degli studi di Roma "Tor Vergata", Rome, Italy.
Luciano LevatoDipartimento Onco-Ematologico, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Marika PorrazzoUOC Oncoematologia, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
Fiorella IlariucciHematology- Azienda USL-IRCCS-Reggio Emilia, Reggio Emilia, Italy.
Riccardo MoiaDivision of Hematology, Department of Translational Medicine, University of Eastern Piedmont and AOU Maggiore della Carità, Novara, Italy.
Myriam FogliettaSC Ematologia, AO S. Croce e Carle, Cuneo, Italy.
Gian Matteo RigolinDepartment of Medical Science, Università degli Studi di Ferrara, Ferrara, Italy.ORCID 0000-0002-8370-5190
Federico ChiurazziDivision of Hematology, Department of Clinical Medicine and Surgery, Università di Napoli Federico II, Napoli, Italy.
Fabio TrastulliDivision of Hematology, Cardarelli Hospital, Naples, Italy.ORCID 0000-0001-6929-0729
Alessandro CelliniHematology and Clinical Immunology Unit, Department of Medicine, University of Padua, Padova, Italy.
Marina DeodatoASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Enrica MartinoHematology Unit AO of Cosenza, Cosenza and Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Luca LaurentiFondazione Policlinico Universitario A. Gemelli -Università Cattolica del Sacro Cuore, Milan, Italy.
Marta CosciaDepartment of Molecular Biotechnology and Health Sciences, University of Torino and Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.
Antonio CuneoDepartment of Medical Science, Università degli Studi di Ferrara, Ferrara, Italy.
Gianluca GaidanoDivision of Hematology, Department of Translational Medicine, University of Eastern Piedmont and AOU Maggiore della Carità, Novara, Italy.ORCID 0000-0002-4681-0151
Davide RossiHematology, Oncology Institute of Southern Switzerland and Institute of Oncology Research, Università della Svizzera Italiana, Bellinzona, Switzerland.
Massimo GentileHematology Unit AO of Cosenza, Cosenza and Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy.
Francesca R MauroHematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy. mauro@bce.uniroma1.it.ORCID 0000-0003-2425-9474

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to define the incidence and risk factors for diffuse large B cell lymphoma variant of RT (DLBCL-RT) in 976 patients with CLL who received ibrutinib therapy. DLBCL-RT was recorded in 83 (8.5%) patients, with a 7-year 15.6% rate. Most patients exhibited clinical signs of aggressive lymphoma, enlarged lymph nodes in 83%, cytopenia in 60%, and Suv

Indexed as

Cell Transformation, NeoplasticLeukemia, Lymphocytic, Chronic, B-CellLymphoma, Large B-Cell, DiffusePyrazolesPyrimidinesAdenineAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedPiperidinesPrognosisAdenineibrutinibPiperidinesPyrazolesPyrimidines

Identifiers

PMID40562789
PMCPMC12310524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.