Evidence map›Paper›PMID 40562724›Full record

ArticleEmerging infectious diseases2025

Multicenter Case-Control Study of Behavioral, Environmental, and Geographic Risk Factors for Talaromycosis, Vietnam.

Lottie Brown, Brian Jonat, Vo Trieu Ly, Nguyen Le Nhu Tung, Pham Si Lam, Nguyen Tat Thanh, Dang Thi Ngoc Bich, Vu Phuong Thao, Nguyen Thi Mai Thu, Ngo Thi Hoa and 1 more

Abstract readMulticenter Study
In one paragraph

Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Development and Clinical Evaluation of a Novel Talaromyces marneffei Mp1p Lateral Flow Assay for Rapid Diagnosis of Talaromycosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Clinical Performance of a Mp1p Antibody Detection Immunoassay For Talaromycosis.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lottie Brown
Brian Jonat
Vo Trieu Ly
Nguyen Le Nhu Tung
Pham Si Lam
Nguyen Tat Thanh
Dang Thi Ngoc Bich
Vu Phuong Thao
Nguyen Thi Mai Thu
Ngo Thi Hoa
Thuy Le

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5M
Liposomal Amphotericin B and Flucytosine Antifungal Strategies for Talaromycosis (LAmB-FAST)R01AI181764 · NIAID · DUKE UNIVERSITY · PI Thuy Le · 2024 to 2026
$3.9M
Development, Clinical Validation, and Readiness for Implementation of a Novel Mp1p D4 Poin Diagnosis of Talaromycosist of Care Test for RapidR01AI177098 · NIAID · DUKE UNIVERSITY · PI Ashutosh Chilkoti, Thuy Le · 2023 to 2026
$2.8M
Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast AsiaR01AI143409 · NIAID · DUKE UNIVERSITY · PI LE, THUY · 2019 to 2024
$2.8M
Tropical Medicine Research Center for Talaromycosis in VietnamU01AI169358 · NIAID · DUKE UNIVERSITY · PI Thuy Le · 2022 to 2026
$2.5M
NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI143409NIAID NIH HHS R01 AI177098NIAID NIH HHS R01 AI181764NIAID NIH HHS U01 AI169358
6 · The paper itself

Abstract

Talaromycosis is a life-threatening fungal disease that primarily affects immunocompromised persons in Southeast Asia. We conducted a multicenter, case-control study recruiting participants with advanced HIV disease in Vietnam; 205 case-patients with culture-confirmed talaromycosis were matched to 405 control-patients by age, sex, and CD4 count. Occupational exposure to tropical plants (odds ratio [OR] 1.73 [95% CI 1.10-2.73]; p = 0.017) and to farmed animals (OR 2.07 [95% CI 1.20-3.55]; p = 0.009) were independent risk factors for talaromycosis. Talaromycosis risk was higher in participants from highland regions than in persons from lowland regions (p<0.05). Participants from lowland regions who had lived or traveled to highland regions had a higher risk for talaromycosis (OR 3.15 [95% CI 1.49-6.64]; p = 0.003). This study confirms the epidemiologic correlation between talaromycosis and soil exposure and demonstrates an epidemiologic link between talaromycosis and residence in or travel to highland regions of Vietnam.

Indexed as

MycosesAdultAnimalsCase-Control StudiesFemaleHIV InfectionsHumansMaleMiddle AgedOccupational ExposureRisk FactorsVietnambamboo ratfungiHIV/AIDS and other retrovirusespenicilliosisPenicillium marneffeirisk factorsTalaromyces marneffeitalaromycosisVietnam

Identifiers

PMID40562724
PMCPMC12205468

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.