ArticleRMD open2025
Clinical and genetic determinants of worse sexual experience in male patients with radiographic axial spondyloarthritis: a multimodal study.
Article in RMD open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From arthritis to erectile dysfunction: potential pathophysiological mechanisms and multidisciplinary integrated management.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe expression and experience of sexuality is a key part of an individual's self-identity, yet it is often overlooked in clinical settings. This study aims to evaluate the impact of radiographic axial spondyloarthritis (r-axSpA) on sexual experience in male patients, identify contributing factors and explore the potential causal relationship between r-axSpA and erectile dysfunction (ED).
methodsWe assessed the sexual experience of 113 male patients with r-axSpA and 73 healthy people using the Sexual Experience Questionnaire in the cross-sectional study. Linear regression analysis was used to explore the contributions of clinical factors to worse sexual experience. A two-sample Mendelian randomisation (MR) design was conducted to examine the potential causal association of r-axSpA with the risk of ED.
resultsThere was a significant difference in the total sexual experience score between patients with r-axSpA and healthy controls (41.81±8.71 vs 50.23±8.82, p<0.001). Patients with r-axSpA had a worse score in all dimensions of sexual experience, including erectile function, individual satisfaction and couple satisfaction, compared with healthy individuals. In the regression model adjusted for age, disease duration and body mass index, disease activity (Bath Ankylosing Spondylitis Disease Activity Index), physical function (Bath Ankylosing Spondylitis Functional Index), mobility (Bath Ankylosing Spondylitis Metrology Index, chest expansion and finger-floor distance), health index (Assessment of SpondyloArthritis international Society Health Index), sleep quality (Pittsburgh Sleep Quality Index) and psychological status (Hospital Anxiety and Depression Scale (HADS), HADS-Anxiety and HADS-Depression) were significant determinants of sexual experience. The two-sample MR analysis demonstrated no causal effect of r-axSpA on the risk of ED (OR: 0.973; 95% CI: 0.824 to 1.149; p=0.749) based on the inverse variance weighted method. Sensitivity analyses supported the result, with no evidence of directional pleiotropy.
conclusionsWorse sexual experience was associated with increased disease activity, reduced mobility, lower health index, poor sleep quality and psychological status. Genetic-level evidence indicated no direct causal relationship between r-axSpA and ED. Therefore, actively assessing disease-related suffering and developing new management strategies are essential for improving sexual experience in patients with r-axSpA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.