Evidence map›Paper›PMID 40562368›Full record

ArticleFundamental & clinical pharmacology2025

Differential Effects of Prenatal Poly I:C Exposure and Antipsychotics on NMDA/GABA Receptors and GSK3β-Mediated Signaling in the Dorsal Raphe Nucleus of Female Rats.

Shiyan Chen, Jiamei Lian, Yueqing Su, Chao Deng

Abstract read
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In one paragraph

Article in Fundamental & clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shiyan ChenDepartment of Neurology, The First Affiliated Hospital of Fujian Medical University, and The Binhai Campus of Fujian Medical University First Hospital, National Regional Medical Center, Fuzhou, China.
Jiamei LianSchool of Medical, Indigenous and Health Sciences, and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Yueqing SuSchool of Medical, Indigenous and Health Sciences, and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.
Chao DengSchool of Medical, Indigenous and Health Sciences, and Molecular Horizons, University of Wollongong, Wollongong, NSW, Australia.ORCID https://orcid.org/0000-0003-1147-5741

Funding

Australian National Health and Medical Research Council (NHMRC) APP1104184Australian National Health and Medical Research Council (NHMRC) APP1125937
6 · The paper itself

Abstract

backgroundThe dorsal raphe nucleus (DRN) is the origin of the 5-HT neurotransmission pathways. The 5-HT, dopamine D2, GABA, and NMDA receptors, as well as the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) and G protein-independent protein kinase B (PKB/Akt)-glycogen synthase kinase 3β (GSK3β) signaling, are involved in the pathophysiology of schizophrenia and are modulated by antipsychotics. However, their pathological changes and antipsychotic modulations in the DRN are not well understood in schizophrenia.

objectivesThis study explored effects of antipsychotics on NMDA and GABA

methodsPrenatal polyriboinosinic-polyribocytidylic acid (Poly I:C) exposure was delivered at gestational Day 15. Female rats were treated with risperidone, olanzapine, or vehicle from postnatal day 70 for 35 days.

resultsPrenatal Poly I:C exposure increased mRNA expression of NMDA receptor Grin2a/2b subunits, the GABA

conclusionThis study suggests that prenatal Poly I:C exposure and antipsychotics differentially modulate NMDA and GABA

Indexed as

Antipsychotic AgentsDorsal Raphe NucleusGlycogen Synthase Kinase 3 betaPoly I-CPrenatal Exposure Delayed EffectsReceptors, N-Methyl-D-AspartateAnimalsCyclic AMP Response Element-Binding ProteinFemaleMaleOlanzapinePregnancyProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyReceptors, GABAAntipsychotic AgentsCyclic AMP Response Element-Binding ProteinGlycogen Synthase Kinase 3 betaGsk3b protein, ratOlanzapinePoly I-CProto-Oncogene Proteins c-aktReceptors, GABAReceptors, GABA-AReceptors, N-Methyl-D-AspartateRisperidoneAKT‐GSK3βantipsychoticsdorsal raphe nucleusmaternal immune activationNMDAPKA

Identifiers

PMID40562368
PMCPMC12196557

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.