Evidence map›Paper›PMID 40562355›Full record

ReviewJournal of advanced research2026

Targeting intracellular mRNA m

Sunil Kumar, Mithun Sinha

Abstract readReview
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sunil KumarDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: kumarsun@iu.edu.
Mithun SinhaDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: mitsinha@iu.edu.

Funding

Implant Biofilm Mediated Immune ResponseR01AI165958 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI Mithun Sinha · 2022 to 2026
$1.8M
NIAID NIH HHS R01 AI165958
6 · The paper itself

Abstract

An impressive clinical success has been achieved in the treatment of various cancers employing immunotherapy and checkpoint blockade antibodies. However, limited therapeutic response has been observed in most of the patients receiving anti-PD1 antibodies remains a critical challenge, underscoring the need for innovative strategies to enhance immunotherapeutic efficacy to overcome these barriers. Several epigenetic drugs targeting DNA and histone proteins have received FDA approval are in the market. However epigenetic drugs targeting mRNA-modification machineries are still in infancy. The discovery of RNA modification enzymes (writers, erasers, and readers) has refuelled the scientific horizons in overcoming the challenges mainly associated with other pharmaceutical drugs. RNA modification especially 'm

Indexed as

AdenosineImmunotherapyNeoplasmsRNA, MessengerRNA Processing, Post-TranscriptionalAnimalsEpigenesis, GeneticHumansAdenosineRNA, MessengerCancer immunotherapyEpitranscriptomicsIntracellular Immune checkpointsm(6)A-methylationRNA-modifying drug

Identifiers

PMID40562355
PMCPMC12957821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.