ReviewJournal of molecular biology2025
NMR in the Age of Modern Biomedical Research and Drug Discovery.
Review in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Tetra-substituted BDPA radicalsChemical communications (Cambridge, England) · 2026Article
- Special Issue "Structural Dynamics of Macromolecules".International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The success of artificial intelligence for structure prediction has led to forecasts of a reduced need for experimental structural biology. Here, we focus on nuclear magnetic resonance (NMR) spectroscopy and its various applications to biomedical research, including and extending beyond structural biology. As a structural tool, NMR is highly complementary to X-ray crystallography and cryo-electron microscopy (cryo-EM) and uniquely suited for studies of intrinsically disordered and dynamic systems in real time. It produces spectral fingerprints of biomolecules at the atomic scale to provide information on the structure, interactions, and motions that occur in solution. We focus on the power of NMR to characterize moderately sized dynamic systems, identify and validate the binding of small molecule ligands to biomolecular targets, and its capacity to further develop and be empowered by artificial intelligence-based structural prediction software. Experimental structural biology begins with sample preparation, and we present recent advancements for overcoming hurdles associated with reconstitution of biological systems for NMR studies and ongoing challenges, including in the application of NMR for cell-based research. NMR is aptly suited to bench-to-bedside efforts for its ability to do metabolomic profiling and follow drug response. We present the capacity of NMR to delve into complexities that are the foundation of biological function and focus on its ongoing challenges and opportunities to apply NMR for the advancement of biomedical research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.