ArticleExperimental neurology2025
Serum evaluation of NFL correlates with histological identification of degenerating axons.
Article in Experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- SARM1 is required for macrophage immunophenotype switching that is essential for nerve repair.bioRxiv : the preprint server for biology · 2026Article
- Development of a paediatric model of diffuse traumatic brain injury in ferrets.Scientific reports · 2026Article
- Serum NfL and GFAP in post-COVID syndrome: minimal evidence of CNS injury after adjusting for confounders.Frontiers in cellular neuroscience · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Serum neurofilament light chain (NF-L) is a promising minimally invasive biomarker for axonal degeneration after neurological damage. The current work demonstrates the utility of serum NF-L as a biomarker for the extent of active axonal degeneration in the injured spinal cord. Adult Sprague Dawley rats received a unilateral C4 contusion (150kdyne). Brainstem and spinal cords were harvested, and serum was collected at 1 h, 6 h, 1 day, 3 days, or 10 days post-injury. Serum NF-L and glial fibrillary acid protein (GFAP) were assessed using the Quanterix® Simoa™ assay. Serial spinal cord cross-sections spanning the caudal medulla to the mid-thoracic spinal cord were stained with the NF-L Degenotag™ MCA-6H63 antibody, which specifically detects degenerating axonal profiles. Sections were qualitatively and quantitatively analyzed for the pattern and extent of axonal degeneration. MCA-6H63 staining and serum NF-L levels peaked at 1-3 days post SCI, and then declined. Further, serum NF-L and the number of MCA-6H63 positive axons were highly correlated across time points (R
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