Evidence map›Paper›PMID 40562037›Full record

ArticleCurrent biology : CB2025

Convergent reduction of olfactory genes and olfactory bulb size in mammalian species at altitude.

Allie M Graham, Elysia Saputra, Bogdan Kirilenko, Jason S Presnell, Arianna Harrington, Chad Huff, Michael Hiller, Nathan Clark

Abstract read
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Olfactory Decline in Elderly at High Altitudes: A Narrative Review.International journal of general medicine · 2026
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Allie M GrahamDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA. Electronic address: graham.allie@ku.edu.
Elysia SaputraJoint Carnegie Mellon University - University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, PA 15213, USA.
Bogdan KirilenkoLOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany; Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany; Institute of Cell Biology and Neuroscience, Faculty of Biosciences, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
Jason S PresnellDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA; Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA.
Arianna HarringtonDepartment of Biology, Southern Utah University, Cedar City, UT 84720, USA.
Chad HuffDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, MD Anderson Cancer Center, University of Texas, Houston, TX 77230, USA.
Michael HillerLOEWE Centre for Translational Biodiversity Genomics, Senckenberganlage 25, 60325 Frankfurt, Germany; Senckenberg Research Institute, Senckenberganlage 25, 60325 Frankfurt, Germany; Institute of Cell Biology and Neuroscience, Faculty of Biosciences, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
Nathan ClarkDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA; Department of Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Funding

RESEARCH TRAINING IN HEMATOLOGYT32DK007115 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN, PRCHAL, JOSEF T · 1986 to 2020
$8.4M
Title: Functional Annotation of Genomes via Phenotypic Convergence within Large Multi-species AlignmentsR01HG009299 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Maria D Chikina, Nathaniel L Clark · 2017 to 2026
$4.1M
Discovery and characterization of ocular regulatory elements through evolutionary analysisR01EY030546 · NEI · UNIVERSITY OF UTAH · PI CHIKINA, MARIA D, CLARK, NATHANIEL L · 2020 to 2024
$2.4M
Plasticity and Nitric Oxide Signaling: Identifying the Novel Adaptive Mechanisms Associated with Response to HypoxiaR00GM144774 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Allie M Graham · 2025 to 2026
$498k
Plasticity and Nitric Oxide Signaling: Identifying the Novel Adaptive Mechanisms Associated with Response to HypoxiaK99GM144774 · NIGMS · UNIVERSITY OF UTAH · PI GRAHAM, ALLIE M · 2022 to 2023
$216k
NEI NIH HHS R01 EY030546NHGRI NIH HHS R01 HG009299NIDDK NIH HHS T32 DK007115NIGMS NIH HHS K99 GM144774NIGMS NIH HHS R00 GM144774
6 · The paper itself

Abstract

The invasion of specialized ecological niches can cause drastic changes to selection regimes, resulting in genomic and phenotypic transformation.

Indexed as

AltitudeMammalsOlfactory BulbReceptors, OdorantAnimalsBiological EvolutionOrgan SizeReceptors, Odorant

Identifiers

PMID40562037
PMCPMC12697247

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.