Evidence map›Paper›PMID 40561884›Full record

ArticleJournal of neuroimmunology2025

Therapeutic potential of S-nitrosoglutathione reductase inhibitor in B cell-driven experimental autoimmune encephalomyelitis.

Jeseong Won, Judong Kim, Fei Qiao, Avtar K Singh, Inderjit Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimmunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeseong WonDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA. Electronic address: wonj@musc.edu.
Judong KimDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Fei QiaoDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Avtar K SinghDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA; Pathology and Laboratory Medicine Service, Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC, USA.
Inderjit SinghDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA; Research Service, Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC, USA. Electronic address: singhi@musc.edu.

Funding

BLRD VA I01 BX002829
6 · The paper itself

Abstract

We previously reported that S-nitrosoglutathione (GSNO) and GSNO reductase inhibitors, which increase endogenous GSNO, mitigate T cell-dependent experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, by suppressing Th1 and Th17 effector T cells while promoting regulatory T cells (Tregs). In this study, we demonstrate that the GSNO reductase inhibitor (N6022) also alleviates B cell-dependent EAE in C57BL/6 mice immunized with recombinant human myelin oligodendrocyte glycoprotein (rhMOG

Indexed as

Aldehyde OxidoreductasesB-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalEnzyme InhibitorsAnimalsBenzamidesB-Lymphocytes, RegulatoryFemaleMiceMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinPyrrolesAldehyde OxidoreductasesBenzamidesEnzyme InhibitorsMyelin-Oligodendrocyte GlycoproteinN6022PyrrolesAutoantibodyB cellsExperimental autoimmune encephalomyelitis (EAE)Multiple sclerosisS-nitrosoglutathione (GSNO)S-nitrosoglutathione reductase (GSNOR)T cells

Identifiers

PMID40561884
PMCPMC13250747

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.