Evidence map›Paper›PMID 40561461›Full record

ArticleAlcohol and alcoholism (Oxford, Oxfordshire)2025

How does taxation affect liver cirrhosis across age groups? An analysis of alcohol control policies on liver cirrhosis outcomes in Lithuania between 2001 and 2022.

Alexander Tran, Huan Jiang, Shannon Lange, Laura Llamosas-Falcón, Janina Petkevičienė, Ričardas Radišauskas, Mindaugas Štelemėkas, Jürgen Rehm

Abstract read
In one paragraph

Article in Alcohol and alcoholism (Oxford, Oxfordshire), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander TranInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, Ontario M5T 1R8, Canada.
Huan JiangInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, Ontario M5T 1R8, Canada.
Shannon LangeInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, Ontario M5T 1R8, Canada.
Laura Llamosas-FalcónInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, Ontario M5T 1R8, Canada.
Janina PetkevičienėHealth Research Institute, Faculty of Public Health, Lithuanian University of Health Sciences, Tilžės str. 18, 47181 Kaunas, Lithuania.
Ričardas RadišauskasDepartment of Environmental and Occupational Medicine, Faculty of Public Health, Lithuanian University of Health Sciences, Tilžės str. 18, 47181 Kaunas, Lithuania.
Mindaugas ŠtelemėkasHealth Research Institute, Faculty of Public Health, Lithuanian University of Health Sciences, Tilžės str. 18, 47181 Kaunas, Lithuania.
Jürgen RehmInstitute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), 250 College Street, Toronto, Ontario M5T 1R8, Canada.

Funding

Evaluation of the impact of alcohol control policies on morbidity and mortality in Lithuania and other Baltic statesR01AA028224 · NIAAA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI REHM, JUERGEN T, ŠTELEMĖKAS, MINDAUGAS · 2020 to 2024
$2.2M
NIAAA NIH HHS 1R01AA028224NIAAA NIH HHS R01 AA028224
6 · The paper itself

Abstract

backgroundLithuania, a European country, has a history of high alcohol consumption per capita. To reduce harm, Lithuania has implemented the World Health Organization 'best buys' for alcohol control policies, notably two taxation policies in 2008 and 2017. Taxation may affect segments of the population differently; to explore this question, we investigated the effects on liver cirrhosis.

aimsTo analyze the effect of taxation on liver cirrhosis hospitalizations and mortality across four age groups in Lithuania.

methodsUsing a general additive mixed model, we tested taxation on monthly hospitalization and mortality rates between 2001 and 2022 (n = 264 months) across four age groups (young adults: 15-34, middle-aged adults: 35-54, older adults: 55-74, and seniors: 75+ years of age, respectively). We computed standardized hospitalizations and mortality rates (admissions and deaths per 100 000 people) based on summed counts of alcoholic liver disease and fibrosis and cirrhosis of the liver according to the International Classification of Diseases 10th Revision.

findingsTaxation was associated with the largest downward trend in liver cirrhosis mortality among middle-aged and older adults, equivalent to two fewer deaths per 100 000 individuals. In older adults and seniors, taxation was associated with downward trends in hospitalizations, but effects were less robust.

conclusionTaxation may lead to decreases in liver cirrhosis mortality across all age groups but appears to be less consistently impactful for hospitalizations. Younger and middle-aged individuals may experience increased hospitalizations. Taxation appears to impact subsections of the population differently.

Indexed as

Alcohol DrinkingAlcoholic BeveragesLiver CirrhosisLiver Cirrhosis, AlcoholicTaxesAdolescentAdultAgedAge FactorsFemaleHospitalizationHumansLithuaniaMaleMiddle AgedYoung Adultage-specific liver cirrhosisalcohol taxationinterrupted time series analysisliver cirrhosis hospitalizationsliver cirrhosis mortality

Identifiers

PMID40561461
PMCPMC12192443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.