ArticleMacromolecular bioscience2025
Electrohydrodynamic Jetting of Mucoadhesive Protein Nanoparticles as a Chemopreventive Strategy for Oral Squamous Cell Carcinoma.
Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Engineered Fenretinide- and Tocilizumab-Releasing Janus Nanoparticles for Site-Directed Immunochemoprevention of Squamous Cell Carcinoma of the Lung.Pharmaceutics · 2025Article
- Electrohydrodynamic Jetting of Mucoadhesive Protein Nanoparticles as a Chemopreventive Strategy for Oral Squamous Cell Carcinoma.Macromolecular bioscience · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Intraepithelial delivery of cancer preventive therapies for oral squamous cell carcinoma (OSCC) has been limited by factors such as rapid mucus turnover, enzymatic degradation, and salivary clearance. These challenges, coupled with poor solubility and associated low bioavailability, have hampered clinical progress. To address these challenges, we present an effective method for encapsulation and sustained release of poorly soluble, apolar therapeutics via mucoadhesive protein nanoparticles (PNPs). To demonstrate feasibility, PNPs loaded with N-(4-hydroxyphenyl) retinamide (4HPR, fenretinide), a hydrophobic chemopreventive compound with low solubility were produced via a three-step process: 1) high-pressure homogenization to solubilize and stabilize 4HPR via association with human serum albumin (HSA), 2) electrohydrodynamic (EHD) jetting of albumin-bound 4HPR to formulate 4HPR-HSA PNPs, and 3) collection of the nanoparticles in the presence of a polycationic compound to infer mucoadhesive properties and physiological stability. This methodology resulted in the effective synthesis of environmentally stable 4HPR-loaded PNPs, which featured an average size of 192 ± 21 nm, a surface zeta potential of +31 ± 6 mV in water, and overall 4HPR loadings of up to 7.1 wt.%. In vitro activation of the apoptosis execution phase enzyme, caspase-3, confirmed sustained release and biological activity of 4HPR. Enhanced binding capacity with mucin (K
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Registered trials
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