Evidence map›Paper›PMID 40561182›Full record

ArticleJournal of cellular and molecular medicine2025

Time-Dependent Effects of Low-Intensity Pulsed Ultrasound on Apoptosis and Autophagy in Malignant Melanoma Stem Cells.

Omer Dikici, Berrin Ozdil, Taha Kadir Yesin, Aylin Dikici, Yasemin Adalı, Huseyin Aktug

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Omer DikiciDepartment of Stem Cell, Institute of Health Sciences, Ege University, Izmir, Turkiye.ORCID 0000-0001-6134-8316
Berrin OzdilDepartment of Histology and Embryology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkiye.ORCID 0000-0001-6081-2308
Taha Kadir YesinDepartment of Histology and Embryology, Faculty of Medicine, Ege University, Izmir, Turkiye.ORCID 0000-0002-3789-3290
Aylin DikiciDepartment of Stem Cell, Institute of Health Sciences, Ege University, Izmir, Turkiye.ORCID 0000-0002-2803-7361
Yasemin AdalıCentre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.ORCID 0000-0002-6314-4816
Huseyin AktugDepartment of Histology and Embryology, Faculty of Medicine, Ege University, Izmir, Turkiye.ORCID 0000-0003-4150-8495

Funding

Ege University Scientific Research Projects Coordination Unit 20785
6 · The paper itself

Abstract

Cancer stem cells (CSCs) in malignant melanoma contribute to therapeutic resistance and tumour recurrence. While low-intensity pulsed ultrasound (LIPUS) has been proposed as a non-invasive strategy to induce cell death, its effects on CSC-specific apoptotic and autophagic responses remain unclear. This study aimed to explore the time-dependent effects of LIPUS on apoptosis and autophagy in CD133+ melanoma CSCs and CD133- non-stem melanoma cells. Human melanoma cells (CHL-1) were sorted via FACS into CD133+ and CD133- populations. Cells were exposed to LIPUS (1 MHz, 20% duty cycle, 1 W/cm

Indexed as

ApoptosisAutophagyMelanomaNeoplastic Stem CellsUltrasonic WavesAC133 AntigenCaspase 3Caspase 8Cell Line, TumorHumansTime FactorsTOR Serine-Threonine KinasesAC133 AntigenCaspase 3Caspase 8MTOR protein, humanPROM1 protein, humanTOR Serine-Threonine Kinasesautophagy, apoptosis, mechanobiologycancer stem cellLIPUSmelanoma

Identifiers

PMID40561182
PMCPMC12191408

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.