Evidence map›Paper›PMID 40561039›Full record

ArticleScience advances2025

Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage.

Joanne Muter, Chow-Seng Kong, Mireia Taus Nebot, Maria Tryfonos, Pavle Vrljicak, Paul J Brighton, Danai B Dimakou, Megan Vickers, Hiroyuki Yoshihara, Sascha Ott and 8 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Joanne MuterWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0002-6194-0165
Chow-Seng KongWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0009-0007-3446-9228
Mireia Taus NebotWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0009-0005-9051-9141
Maria TryfonosWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.
Pavle VrljicakWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0009-0004-9557-4820
Paul J BrightonWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0002-6908-3794
Danai B DimakouDepartment of Clinical Immunology Service, University of Birmingham, B15 2TT Birmingham, UK.ORCID 0000-0002-7085-0188
Megan VickersWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0009-0005-5809-7815
Hiroyuki YoshiharaWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0001-9306-2849
Sascha OttWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0002-5411-8114
Bee K TanDepartment of Cardiovascular Sciences, University of Leicester, LE1 7RH Leicester, UK.ORCID 0000-0001-5836-0613
Phillip R BennettTommy's National Centre for Miscarriage Research, Imperial College London, W12 0HS London, UK.ORCID 0000-0002-6253-4919
Siobhan QuenbyWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0003-3221-5471
Alex RichterDepartment of Clinical Immunology Service, University of Birmingham, B15 2TT Birmingham, UK.ORCID 0000-0003-2885-1299
Hilde Van de VeldeResearch Group Genetics, Reproduction and Development, Vrije Universiteit Brussel, 1050 Brussels, Belgium.ORCID 0000-0001-8601-6561
Emma S LucasWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0002-8571-8921
Thomas M RawlingsWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0002-1027-9362
Jan J BrosensWarwick Medical School, Division of Biomedical Sciences, University of Warwick, CV4 7AL Coventry, UK.ORCID 0000-0003-0116-9329

Funding

Wellcome Trust
6 · The paper itself

Abstract

In every menstrual cycle, progesterone acting on estrogen-primed endometrium elicits an inflammatory decidual reaction, rendering it poised for embryo implantation and transformation into the decidua of pregnancy. Here, we show that the sequential functions of the decidual reaction-implantation and decidualization-pivot on the time-sensitive loss of progesterone-resistant

Indexed as

Abortion, SpontaneousDeciduaEndometriumAbortion, HabitualAdultCell ProliferationEmbryo ImplantationFemaleHumansKiller Cells, NaturalPregnancyProgesteroneRecurrenceStromal CellsProgesterone

Identifiers

PMID40561039
PMCPMC12189951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.