Evidence map›Paper›PMID 40561023›Full record

ArticleScience advances2025

A reusable hydrogel biosensor array with electrically responsive hydrogel interfaces for noninvasive locating of perforating arteries.

Ganguang Yang, Yuqi Qiu, Bo Pang, Wei Guo, Shaoyu Liu, Qingyang Zheng, Sen Zhou, Jia Tian, Wei Liu, Bin Xie and 5 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. A soft electrode array with reconfigurable hydrogel interfaces for high-fidelity neurophysiological monitoring during craniotomy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ganguang YangFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0003-2888-5288
Yuqi QiuFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0009-0000-0139-5348
Bo PangFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Wei GuoFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Shaoyu LiuFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Qingyang ZhengFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Sen ZhouFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Jia TianDepartment of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.ORCID 0000-0003-0677-6646
Wei LiuDepartment of Geriatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.ORCID 0000-0002-3802-9680
Bin XieFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0001-9031-5900
Tianzhao BuFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
Changsheng WuDepartment of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore.ORCID 0000-0002-0921-6356
Zhouping YinFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0009-0000-7091-2265
Yutian LiuDepartment of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.ORCID 0000-0002-6751-321X
Hao WuFlexible Electronics Research Center, State Key Laboratory of Intelligent Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.ORCID 0000-0003-1494-0848

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achieving accurate locating of perforating arteries (PAs) has great clinical value in various biomedical applications, such as free flap transfer. However, the anatomical variability of these arteries presents a major challenge in PA locating, and existing methods have various disadvantages, limiting their applications. Here, we propose a reusable and flexible hydrogel biosensor array for noninvasive, precise, and efficient PA locating. Particularly, we develop electrically responsive hydrogels to establish rapidly detachable device/hydrogel interfaces, endowing the reusability of the biosensor array. Meanwhile, the adhesion of hydrogel/skin interfaces is also enhanced to facilitate high-fidelity signal acquisition. By analyzing the photoplethysmography (PPG) infrared (IR) signals, the biosensor array can accurately and responsively locate PAs across different types of free flaps in clinical cases, outperforming existing techniques. This biosensor array represents a promising platform for PA locating. The strategy of hydrogel interface design paves the way for the development of reusable flexible electronics in biomedical applications to avoid cross-infection and reduce device costs.

Indexed as

ArteriesBiosensing TechniquesHydrogelsElectricityHumansPhotoplethysmographyHydrogels

Identifiers

PMID40561023
PMCPMC12190022

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.