Evidence map›Paper›PMID 40561001›Full record

ArticleScience translational medicine2025

Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus.

Rithwik Narendra, Hoang Van Phan, Sarah L Patterson, Ana Almonte-Loya, Emily C Lydon, Cristina Lanata, Christina Love, Joonsuk Park, Michiko Shimoda, Lisa Barcellos and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Rithwik NarendraDivision of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-1292-1336
Hoang Van PhanDivision of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-0162-4283
Sarah L PattersonDivision of Rheumatology, University of California, San Francisco, San Francisco, CA 94118, USA.ORCID 0000-0002-6661-019X
Ana Almonte-LoyaUCSF Co-Labs, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-2798-3142
Emily C LydonDivision of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-3510-6254
Cristina LanataNational Human Genome Research Institute, Bethesda, MD 20894, USA.ORCID 0000-0002-6017-4921
Christina LoveDivision of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94143, USA.
Joonsuk ParkUniversity of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0009-0001-4211-8328
Michiko ShimodaDepartment of Experimental Medicine, University of California, San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-6627-4624
Lisa BarcellosUniversity of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-0303-3479
Honey MekonenUniversity of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0001-7959-1151
Angela DetweilerUniversity of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-7026-5467
Padmini DeosthaleDivision of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94143, USA.
Norma NeffUniversity of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-7141-5420
Lindsey A CriswellNational Human Genome Research Institute, Bethesda, MD 20894, USA.ORCID 0000-0002-0761-7543
Lenka MaliskovaUCSF Co-Labs, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-7677-3833
Walter EckalbarUCSF Co-Labs, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-2520-7852
Gabriela K FragiadakisDivision of Rheumatology, University of California, San Francisco, San Francisco, CA 94118, USA.ORCID 0000-0001-9703-2591
Jinoos YazdanyDivision of Rheumatology, University of California, San Francisco, San Francisco, CA 94118, USA.ORCID 0000-0002-3508-4094
Maria Dall'EraDivision of Rheumatology, University of California, San Francisco, San Francisco, CA 94118, USA.ORCID 0000-0001-7439-2316
Patricia KatzDivision of Rheumatology, University of California, San Francisco, San Francisco, CA 94118, USA.ORCID 0000-0002-8146-2519
Chun Jimmie YeDivision of Rheumatology, University of California, San Francisco, San Francisco, CA 94118, USA.ORCID 0000-0001-6560-3783
Marina SirotaBakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-7246-6083
Charles R LangelierDivision of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-6708-4646

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
BIOLOGY OF INFECTIOUS DISEASES TRAINING PROGRAMT32AI007641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2000 to 2026
$6.9M
Defining stress REsilience And Mindfulness Effects in Rheumatoid Arthritis (DREAMER) - admin supplementK23AT011768 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sarah Lynn Patterson · 2022 to 2026
$925k
NCCDPHP CDC HHS U01 DP005120NCCDPHP CDC HHS U01 DP006700NCCDPHP CDC HHS U01 DP006701NCCIH NIH HHS K23 AT011768NIAID NIH HHS P30 AI027763NIAID NIH HHS T32 AI007641
6 · The paper itself

Abstract

In the general population, aging is associated with an increase in systemic inflammation and chronic disease burden. However, in systemic lupus erythematosus (SLE), older age is uniquely associated with a decrease in disease activity, suggesting a distinct relationship between aging and inflammation. Using a multiomic approach, we compared aging-related changes in the peripheral blood immune profiles of 287 patients with SLE and 928 healthy controls. In patients with SLE, aging correlated with lower expression of interferon (IFN)-stimulated genes (ISGs) across multiple cell types, decreased plasma IFN-α2, and differential genome methylation. Both patients with SLE and controls demonstrated age-related declines in naïve T cells, but only patients with SLE exhibited increases in CD56

Indexed as

AgingEpigenesis, GeneticInterferonsLupus Erythematosus, SystemicSignal TransductionAdultAgedCase-Control StudiesDNA MethylationFemaleHumansMaleMiddle AgedYoung AdultInterferons

Identifiers

PMID40561001
PMCPMC13012812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.