ArticleACS sensors2025
Extending the Operational Lifespan of Nucleic Acid-Based Electrochemical Sensors via Protection against Hydrogen Peroxide and Oligonucleotide Displacement.
Article in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Continuous Molecular Monitoring Using Electrochemical Aptamer-Based Sensors: Remaining Challenges for Long-Term In Vivo Deployment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Miniaturization of Aptasensors in Organic Electrochemical Transistors for Sensitivity Enhancement.Analytical chemistry · 2026Article
- A Sensitive DNA Bowtie Sensor for Calibration-Free Sex Hormone Detection Using Analyte-DNA Conjugates and Multiple Redox Labels.ACS measurement science au · 2026Article
- A robust Au-C[triple bond, length as m-dash]C anchoring group greatly improves the signal stability of electrochemical aptamer-based sensors forChemical science · 2026Article
- Catheter-Electrode System for Continuous Aptamer-Based Sensing in the Rat Subcutaneous Space.ECS sensors plus · 2025Article
- Cyclooctyne-Functionalized N-Heterocyclic Carbenes for Click Coupling of Sensing Oligonucleotides to Gold Surfaces.ACS sensors · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Nucleic acid-based electrochemical sensors (NBEs) have emerged as a promising approach to continuous molecular monitoring in vivo. NBEs consist of electrically conductive gold surfaces coated with self-assembled monolayers of a mixture of electrode-passivating alkylthiols and functional alkylthiol-modified oligonucleotides (oligos). These oligos also display binding sites for target analytes and are modified with redox reporters capable of transferring electrons to the underlying gold electrode. Although sufficiently robust for continuous, multihour sensing of small molecules and proteins in biological fluids both in vitro and in vivo, the operational lifespan of NBEs under continuous interrogation is only 12 h in biological fluids. To address this issue, we present rigorous experimental evidence using scanning electrochemical microscopy (SECM) showing that applying a negative potential bias during NBE interrogation promotes the localized generation of hydrogen peroxide (H
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Registered trials
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