Evidence map›Paper›PMID 40560726›Full record

ArticleCell reports2025

Activity-dependent development of synaptic circuits mediates direction selectivity in an axis-specific manner.

Karina Bistrong, Rachana Deven Somaiya, Eugene Y Liang, Benjamin E Smith, Marla B Feller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Cholinergic Waves Have a Modest Influence on the Transcriptome of Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karina BistrongDepartment of Neuroscience & Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Rachana Deven SomaiyaDepartment of Neuroscience & Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Eugene Y LiangDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Benjamin E SmithSchool of Optometry, University of California, Berkeley, Berkeley, CA 94720, USA.
Marla B FellerDepartment of Neuroscience & Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: mfeller@berkeley.edu.

Funding

UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RICHARD H KRAMER · 1985 to 2026
$16.4M
The Function of Neural Activity in Developing RetinaR01EY013528 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Marla Feller · 2002 to 2026
$8.1M
Development of direction selectivity in the retinaR01EY019498 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Marla Feller · 2009 to 2026
$6.6M
Assessing direction selectivity map development in the retinaF31EY033646 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BISTRONG, KARINA · 2022 to 2025
$174k
NEI NIH HHS F31 EY033646NEI NIH HHS P30 EY003176NEI NIH HHS R01 EY013528NEI NIH HHS R01 EY019498
6 · The paper itself

Abstract

The optokinetic reflex (OKR), which stabilizes images on the retina as a mouse navigates its environment, originates in direction-selective ganglion cells (DSGCs). A mouse model that lacks cholinergic retinal waves, the β2-nAChR-KO mouse, does not develop horizontal direction selectivity but preserves vertical direction selectivity. Here, we demonstrate that the absence of horizontal direction selectivity in β2-nAChR-KO mice results in a loss of the OKR along the horizontal axis, consistent with previous findings on optomotor response. In addition, we observe diminished asymmetric inhibition onto horizontal-preferring DSGCs. In contrast, OKR along the vertical axis and asymmetric inhibition onto vertical-preferring DSGCs is maintained. Dual whole-cell voltage-clamp recordings show that this decrease in asymmetric inhibition is attributable to a reduction in GABAergic conductance between horizontal-preferring DSGCs and their presynaptic partner. These results indicate that, before the onset of vision, spontaneous activity selectively influences the formation of precise wiring essential for motion detection along the horizontal axis.

Indexed as

Retinal Ganglion CellsSynapsesAnimalsMiceMice, Inbred C57BLMice, KnockoutNystagmus, OptokineticReceptors, NicotinicReceptors, Nicotinicconductance modelCP: Neurosciencefeature detectionRetinal circuitsretinal ganglion cellstarburst amacrine celltwo-photon

Identifiers

PMID40560726
PMCPMC12352496

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.